BET1

From Wikipedia, the free encyclopedia

BET1 homolog (S. cerevisiae)

Identifiers

BET1; DKFZp781C0425; HBET1

External IDs

OMIM: 605456 MGI: 1343104 HomoloGene: 38108

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• Golgi membrane • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• ER to Golgi vesicle-mediated transport • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005868 (mRNA)
NP_005859 (protein)

NM_009748 (mRNA)
NP_033878 (protein)

Location

Chr 7: 93.43 - 93.47 Mb

Chr 6: 4.03 - 4.04 Mb

Pubmed search

[1]

[2]

BET1 homolog (S. cerevisiae), also known as BET1, is a human gene.^[1]

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: BET1 BET1 homolog (S. cerevisiae).

[edit] Further reading

Waters MG, Pfeffer SR (1999). "Membrane tethering in intracellular transport.". Curr. Opin. Cell Biol. 11 (4): 453-9. PMID 10449330.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport.". J. Biol. Chem. 276 (29): 27480-7. doi:10.1074/jbc.M102786200. PMID 11323436.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Zhang T, Wong SH, Tang BL, et al. (1997). "The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus.". J. Cell Biol. 139 (5): 1157-68. PMID 9382863.
Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.". Cell 89 (1): 149-58. PMID 9094723.
Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus.". J. Biol. Chem. 271 (10): 5671-9. PMID 8621431.