Berberine reductase

From Wikipedia, the free encyclopedia

In enzymology, a berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction

(R)-canadine + 2 NADP⁺ berberine + 2 NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-canadine and NADP⁺, whereas its 3 products are berberine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.

[edit] References

• IUBMB entry for 1.5.1.31
• BRENDA references for 1.5.1.31 (Recommended.)
• PubMed references for 1.5.1.31
• PubMed Central references for 1.5.1.31
• Google Scholar references for 1.5.1.31
• Bauer W and Zenk MH (1991). "Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro". Tetrahedron Lett. 32: 487–490. doi:10.1016/S0040-4039(00)79475-5. 

[edit] External links

• IUBMB entry for 1.5.1.31

• KEGG entry for 1.5.1.31

• BRENDA entry for 1.5.1.31

• NiceZyme view of 1.5.1.31

• EC2PDB: PDB structures for 1.5.1.31

• PRIAM entry for 1.5.1.31

• PUMA2 entry for 1.5.1.31

• IntEnz: Integrated Enzyme entry for 1.5.1.31

• MetaCyc entry for 1.5.1.31

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050623: berberine reductase

• AMIGO entry for GO code 0050623: berberine reductase