Benzylthiouracil

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Benzylthiouracil
Systematic (IUPAC) name
1-(1-cyclohexa-2,4-dienylmethyl)-7-thia-
3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one
Identifiers
CAS number 6336-50-1
ATC code H03BA03
PubChem 685814
Chemical data
Formula C11H10N2OS 
Mol. mass 218.276 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral

Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

[edit] Adverse effects

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][2][3][4]

[edit] References

  1. ^ Tieulie N, Huong DL, Andreu M, et al (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]" (in French). Rev Med Interne 23 (10): 853–6. PMID 12428489. 
  2. ^ Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]" (in French). Rev Med Interne 23 (10): 857–61. PMID 12428490. 
  3. ^ Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]" (in French). Presse médicale 33 (19 Pt 1): 1331–3. PMID 15615240. 
  4. ^ Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr 165 (7): 435–6. doi:10.1007/s00431-005-0053-4. PMID 16622664.