Benzyl-2-methyl-hydroxybutyrate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a benzyl-2-methyl-hydroxybutyrate dehydrogenase (EC 1.1.1.217) is an enzyme that catalyzes the chemical reaction

benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP⁺ benzyl 2-methyl-3-oxobutanoate + NADPH + H⁺

Thus, the two substrates of this enzyme are benzyl (2R,3S)-2-methyl-3-hydroxybutanoate and NADP⁺, whereas its 3 products are benzyl 2-methyl-3-oxobutanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase. This enzyme is also called benzyl 2-methyl-3-hydroxybutyrate dehydrogenase.

[edit] References

• IUBMB entry for 1.1.1.217
• BRENDA references for 1.1.1.217 (Recommended.)
• PubMed references for 1.1.1.217
• PubMed Central references for 1.1.1.217
• Google Scholar references for 1.1.1.217
• Furuichi A, Akita H, Matsukura H, Oishi T and Horikoshi K (1985). "Purification and properties of an asymmetric reduction enzyme of 2-methyl-3-oxobutyrate in baker's yeast". Agric. Biol. Chem. 49: 2563–2570. 

[edit] External links

The CAS registry number for this enzyme class is 99332-62-4.

• IUBMB entry for 1.1.1.217

• KEGG entry for 1.1.1.217

• BRENDA entry for 1.1.1.217

• NiceZyme view of 1.1.1.217

• EC2PDB: PDB structures for 1.1.1.217

• PRIAM entry for 1.1.1.217

• PUMA2 entry for 1.1.1.217

• IntEnz: Integrated Enzyme entry for 1.1.1.217

• MetaCyc entry for 1.1.1.217

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047027: benzyl-2-methyl-hydroxybutyrate dehydrogenase

• AMIGO entry for GO code 0047027: benzyl-2-methyl-hydroxybutyrate dehydrogenase