Benzoylformate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a benzoylformate decarboxylase (EC 4.1.1.7) is an enzyme that catalyzes the chemical reaction

benzoylformate + H⁺ benzaldehyde + CO₂

Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1BFD, 1MCZ, 1PI3, 1PO7, 1Q6Z, 1YNO, 2FN3, and 2FWN.

[edit] References

• IUBMB entry for 4.1.1.7
• BRENDA references for 4.1.1.7 (Recommended.)
• PubMed references for 4.1.1.7
• PubMed Central references for 4.1.1.7
• Google Scholar references for 4.1.1.7
• GUNSALUS CF, STANIER RY, GUNSALUS IC (1953). "The enzymatic conversion of mandelic acid to benzoic acid. III Fractionation and properties of the soluble enzymes". J. Bacteriol. 66: 548–53. PMID 13108854. 

[edit] External links

The CAS registry number for this enzyme class is 9025-00-7.

• IUBMB entry for 4.1.1.7

• KEGG entry for 4.1.1.7

• BRENDA entry for 4.1.1.7

• NiceZyme view of 4.1.1.7

• EC2PDB: PDB structures for 4.1.1.7

• PRIAM entry for 4.1.1.7

• PUMA2 entry for 4.1.1.7

• IntEnz: Integrated Enzyme entry for 4.1.1.7

• MetaCyc entry for 4.1.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050695: benzoylformate decarboxylase

• AMIGO entry for GO code 0050695: benzoylformate decarboxylase