Benzoyl-CoA reductase

From Wikipedia, the free encyclopedia

In enzymology, a benzoyl-CoA reductase (EC 1.3.99.15) is an enzyme that catalyzes the chemical reaction

benzoyl-CoA + reduced acceptor + 2 ATP + 2 H₂O cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate

The 4 substrates of this enzyme are benzoyl-CoA, reduced acceptor, ATP, and H₂O, whereas its 4 products are cyclohexa-1,5-diene-1-carbonyl-CoA, acceptor, ADP, and phosphate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming). This enzyme is also called benzoyl-CoA reductase (dearomatizing). This enzyme participates in benzoate degradation via coa ligation. It has 2 cofactors: manganese, and Magnesium.

[edit] References

• IUBMB entry for 1.3.99.15
• BRENDA references for 1.3.99.15 (Recommended.)
• PubMed references for 1.3.99.15
• PubMed Central references for 1.3.99.15
• Google Scholar references for 1.3.99.15
• Boll M, Fuchs G (1995). "Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172". Eur. J. Biochem. 234: 921–33. doi:10.1111/j.1432-1033.1995.921_a.x. PMID 8575453. 

[edit] External links

The CAS registry number for this enzyme class is 176591-18-7.

• IUBMB entry for 1.3.99.15

• KEGG entry for 1.3.99.15

• BRENDA entry for 1.3.99.15

• NiceZyme view of 1.3.99.15

• EC2PDB: PDB structures for 1.3.99.15

• PRIAM entry for 1.3.99.15

• PUMA2 entry for 1.3.99.15

• IntEnz: Integrated Enzyme entry for 1.3.99.15

• MetaCyc entry for 1.3.99.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018522: benzoyl-CoA reductase

• AMIGO entry for GO code 0018522: benzoyl-CoA reductase