Benzoyl-CoA 3-monooxygenase

From Wikipedia, the free encyclopedia

In enzymology, a benzoyl-CoA 3-monooxygenase (EC 1.14.13.58) is an enzyme that catalyzes the chemical reaction

benzoyl-CoA + NADPH + H⁺ + O₂ 3-hydroxybenzoyl-CoA + NADP⁺ + H₂O

The 4 substrates of this enzyme are benzoyl-CoA, NADPH, H⁺, and O₂, whereas its 3 products are 3-hydroxybenzoyl-CoA, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating). This enzyme is also called benzoyl-CoA 3-hydroxylase.

[edit] References

• IUBMB entry for 1.14.13.58
• BRENDA references for 1.14.13.58 (Recommended.)
• PubMed references for 1.14.13.58
• PubMed Central references for 1.14.13.58
• Google Scholar references for 1.14.13.58
• Niemetz R, Altenschmidt U, Brucker S, Fuchs G (1995). "Benzoyl-coenzyme-A 3-monooxygenase, a flavin-dependent hydroxylase Purification, some properties and its role in aerobic benzoate oxidation via gentisate in a denitrifying bacterium". Eur. J. Biochem. 227: 161–8. doi:10.1111/j.1432-1033.1995.tb20372.x. PMID 7851381. 

[edit] External links

The CAS registry number for this enzyme class is 151616-61-4.

• IUBMB entry for 1.14.13.58

• KEGG entry for 1.14.13.58

• BRENDA entry for 1.14.13.58

• NiceZyme view of 1.14.13.58

• EC2PDB: PDB structures for 1.14.13.58

• PRIAM entry for 1.14.13.58

• PUMA2 entry for 1.14.13.58

• IntEnz: Integrated Enzyme entry for 1.14.13.58

• MetaCyc entry for 1.14.13.58

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047090: benzoyl-CoA 3-monooxygenase

• AMIGO entry for GO code 0047090: benzoyl-CoA 3-monooxygenase