Benzene 1,2-dioxygenase

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In enzymology, a benzene 1,2-dioxygenase (EC 1.14.12.3) is an enzyme that catalyzes the chemical reaction

benzene + NADH + H⁺ + O₂ cis-cyclohexa-3,5-diene-1,2-diol + NAD⁺

The 4 substrates of this enzyme are benzene, NADH, H⁺, and O₂, whereas its two products are cis-cyclohexa-3,5-diene-1,2-diol and NAD⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use include benzene hydroxylase, and benzene dioxygenase. This enzyme participates in naphthalene and anthracene degradation. It has 4 cofactors: FAD, Iron, Sulfur, and Iron-sulfur.

[edit] References

• IUBMB entry for 1.14.12.3
• BRENDA references for 1.14.12.3 (Recommended.)
• PubMed references for 1.14.12.3
• PubMed Central references for 1.14.12.3
• Google Scholar references for 1.14.12.3
• Gibson DT, Koch JR, Kallio RE (1968). "Oxidative degradation of aromatic hydrocarbons by microorganisms. I Enzymatic formation of catechol from benzene". Biochemistry. 7: 2653–62. doi:10.1021/bi00847a031. PMID 4298226. 

[edit] External links

The CAS registry number for this enzyme class is 9075-66-5.

• IUBMB entry for 1.14.12.3

• KEGG entry for 1.14.12.3

• BRENDA entry for 1.14.12.3

• NiceZyme view of 1.14.12.3

• EC2PDB: PDB structures for 1.14.12.3

• PRIAM entry for 1.14.12.3

• PUMA2 entry for 1.14.12.3

• IntEnz: Integrated Enzyme entry for 1.14.12.3

• MetaCyc entry for 1.14.12.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018619: benzene 1,2-dioxygenase

• AMIGO entry for GO code 0018619: benzene 1,2-dioxygenase