Beclamide

From Wikipedia, the free encyclopedia

Beclamide
Systematic (IUPAC) name
N-benzyl-3-chloropropionamide
Identifiers
CAS number	501-68-8
ATC code	N03AX30
PubChem	10391
Chemical data
Formula	?
Mol. mass	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a propionate and was used as a sedative and as an anticonvulsant.

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.

Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. It is no longer used as an AED. Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.

[edit] References

• The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
• Beclamide (in French)

v • d • e Anticonvulsants (N03) Barbiturates Barbexaclone, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone Hydantoins Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin Oxazolidinediones Ethadione, Paramethadione, Trimethadione Succinimides Ethosuximide, Mesuximide, Phensuximide Benzodiazepines Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nimetazepam, Nitrazepam, Temazepam Carboxamides Carbamazepine, Oxcarbazepine, Rufinamide Fatty acid derivatives Valpromide, Valnoctamide Carboxylic acids Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine Others GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin -- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide