Bcl-2-interacting killer

From Wikipedia, the free encyclopedia

BCL2-interacting killer (apoptosis-inducing)

Identifiers

BIK; BIP1; BP4; NBK

External IDs

OMIM: 603392 MGI: 1206591 HomoloGene: 924

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• mitochondrial envelope • membrane • integral to membrane
Biological Process:	• induction of apoptosis • apoptotic program • regulation of apoptosis

Orthologs

Human

Mouse

n/a

Refseq

NM_001197 (mRNA)
NP_001188 (protein)

XM_001001652 (mRNA)
XP_001001652 (protein)

Location

Chr 22: 41.84 - 41.86 Mb

Chr 15: 83.35 - 83.37 Mb

Pubmed search

[1]

[2]

BCL2-interacting killer (apoptosis-inducing), also known as BIK, is a human gene.^[1]

The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.^[1]

[edit] References

^ ^a ^b Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing).

[edit] Further reading

Boyd JM, Gallo GJ, Elangovan B, et al. (1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.". Oncogene 11 (9): 1921–8. PMID 7478623.
Chittenden T, Flemington C, Houghton AB, et al. (1996). "A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.". EMBO J. 14 (22): 5589–96. PMID 8521816.
Han J, Sabbatini P, White E (1996). "Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.". Mol. Cell. Biol. 16 (10): 5857–64. PMID 8816500.
Inohara N, Ding L, Chen S, Núñez G (1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).". EMBO J. 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMID 9130713.
Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMID 9463381.
Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.". J. Biol. Chem. 273 (14): 7783–6. PMID 9525867.
Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members.". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646.
Castells A, Ino Y, Louis DN, et al. (1999). "Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.". Gastroenterology 117 (4): 831–7. PMID 10500065.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Verma S, Budarf ML, Emanuel BS, Chinnadurai G (2000). "Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences.". Gene 254 (1-2): 157–62. PMID 10974546.
Jiang A, Clark EA (2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis.". J. Immunol. 166 (10): 6025–33. PMID 11342619.
Federici M, Hribal M, Perego L, et al. (2001). "High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.". Diabetes 50 (6): 1290–301. PMID 11375329.
Zou Y, Peng H, Zhou B, et al. (2002). "Systemic tumor suppression by the proapoptotic gene bik.". Cancer Res. 62 (1): 8–12. PMID 11782349.
Germain M, Mathai JP, Shore GC (2002). "BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria.". J. Biol. Chem. 277 (20): 18053–60. doi:10.1074/jbc.M201235200. PMID 11884414.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gillissen B, Essmann F, Graupner V, et al. (2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.". EMBO J. 22 (14): 3580–90. doi:10.1093/emboj/cdg343. PMID 12853473.
Arena V, Martini M, Luongo M, et al. (2003). "Mutations of the BIK gene in human peripheral B-cell lymphomas.". Genes Chromosomes Cancer 38 (1): 91–6. doi:10.1002/gcc.10245. PMID 12874789.
Hur J, Chesnes J, Coser KR, et al. (2004). "The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2351–6. PMID 14983013.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.