BCL9

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B-cell CLL/lymphoma 9
PDB rendering based on 2gl7.
Available structures: 2gl7
Identifiers
Symbol(s) BCL9; LGS; MGC131591
External IDs OMIM: 602597 MGI: 1924828 HomoloGene: 3191
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 607 77578
Ensembl ENSG00000116128 ENSMUSG00000038256
Uniprot O00512 Q9D219
Refseq NM_004326 (mRNA)
NP_004317 (protein)		 NM_029933 (mRNA)
NP_084209 (protein)
Location Chr 1: 145.48 - 145.56 Mb Chr 3: 97.29 - 97.3 Mb
Pubmed search [1] [2]

B-cell CLL/lymphoma 9, also known as BCL9, is a human gene.[1]

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.[1]

[edit] References

  1. ^ a b Entrez Gene: BCL9 B-cell CLL/lymphoma 9.

[edit] Further reading

  • Willis TG, Zalcberg IR, Coignet LJ, et al. (1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.". Blood 91 (6): 1873–81. PMID 9490669. 
  • Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, et al. (2000). "Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.". Leukemia 13 (12): 1975–81. PMID 10602418. 
  • Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.". Cell 109 (1): 47–60. PMID 11955446. 
  • Knoll A, Dvorák J, Rohrer GA, Cepica S (2002). "Linkage and cytogenetic mapping of the BCL9 gene to porcine chromosome 4.". Anim. Genet. 33 (2): 162–3. PMID 12047235. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development.". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447. 
  • Hoffmans R, Basler K (2004). "Identification and in vivo role of the Armadillo-Legless interaction.". Development 131 (17): 4393–400. doi:10.1242/dev.01296. PMID 15294866. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Sampietro J, Dahlberg CL, Cho US, et al. (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex.". Mol. Cell 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462. 
  • Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272. 
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