BCL3

From Wikipedia, the free encyclopedia

B-cell CLL/lymphoma 3

PDB rendering based on 1k1a.

Available structures: 1k1a, 1k1b

Identifiers

Symbol(s)

BCL3; BCL4; D19S37

External IDs

OMIM: 109560 MGI: 88140 HomoloGene: 81738

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • protein complex
Biological Process:	• protein import into nucleus, translocation • regulation of progression through cell cycle • transcription • regulation of transcription, DNA-dependent • cytoplasmic sequestering of NF-kappaB • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005178 (mRNA)
NP_005169 (protein)

NM_033601 (mRNA)
NP_291079 (protein)

Location

Chr 19: 49.94 - 49.96 Mb

Chr 7: 18.97 - 18.98 Mb

Pubmed search

[1]

[2]

B-cell CLL/lymphoma 3, also known as BCL3, is a human gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.^[1]

[edit] References

^ Entrez Gene: BCL3 B-cell CLL/lymphoma 3.

[edit] Further reading

Franzoso G, Bours V, Park S, et al. (1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.". Nature 359 (6393): 339–42. doi:10.1038/359339a0. PMID 1406939.
Wulczyn FG, Naumann M, Scheidereit C (1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B.". Nature 358 (6387): 597–9. doi:10.1038/358597a0. PMID 1501714.
Bhatia K, Huppi K, McKeithan T, et al. (1991). "Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes.". Oncogene 6 (9): 1569–73. PMID 1923524.
Mills FC, Brooker JS, Camerini-Otero RD (1991). "Sequences of human immunoglobulin switch regions: implications for recombination and transcription.". Nucleic Acids Res. 18 (24): 7305–16. PMID 2124350.
Ohno H, Takimoto G, McKeithan TW (1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.". Cell 60 (6): 991–7. PMID 2180580.
Crossen PE, Kennedy MA, Heaton DC, Morrison MJ (1993). "Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region.". Genes Chromosomes Cancer 8 (1): 60–2. PMID 7691160.
McKeithan TW, Ohno H, Dickstein J, Hume E (1995). "Genomic structure of the candidate proto-oncogene BCL3.". Genomics 24 (1): 120–6. doi:10.1006/geno.1994.1588. PMID 7896265.
Zhang Q, Didonato JA, Karin M, McKeithan TW (1994). "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.". Mol. Cell. Biol. 14 (6): 3915–26. PMID 8196632.
Fujita T, Nolan GP, Liou HC, et al. (1993). "The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.". Genes Dev. 7 (7B): 1354–63. PMID 8330739.
Naumann M, Wulczyn FG, Scheidereit C (1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.". EMBO J. 12 (1): 213–22. PMID 8428580.
Bours V, Franzoso G, Azarenko V, et al. (1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.". Cell 72 (5): 729–39. PMID 8453667.
Nolan GP, Fujita T, Bhatia K, et al. (1993). "The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.". Mol. Cell. Biol. 13 (6): 3557–66. PMID 8497270.
Watanabe N, Iwamura T, Shinoda T, Fujita T (1997). "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation.". EMBO J. 16 (12): 3609–20. doi:10.1093/emboj/16.12.3609. PMID 9218802.
Bundy DL, McKeithan TW (1998). "Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA.". J. Biol. Chem. 272 (52): 33132–9. PMID 9407099.
Weyrich AS, Dixon DA, Pabla R, et al. (1998). "Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5556–61. PMID 9576921.
Na SY, Choi HS, Kim JW, et al. (1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor.". J. Biol. Chem. 273 (47): 30933–8. PMID 9812988.
Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.". Oncogene 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
Na SY, Choi JE, Kim HJ, et al. (1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.". J. Biol. Chem. 274 (40): 28491–6. PMID 10497212.
Neumann M, Fries H, Scheicher C, et al. (2000). "Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells.". Blood 95 (1): 277–85. PMID 10607713.
Brasier AR, Lu M, Hai T, et al. (2001). "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence.". J. Biol. Chem. 276 (34): 32080–93. doi:10.1074/jbc.M102949200. PMID 11387332.