BCL2L10

From Wikipedia, the free encyclopedia

BCL2-like 10 (apoptosis facilitator)

Identifiers

BCL2L10; BCL-B; Boo; Diva; MGC129810; MGC129811

External IDs

OMIM: 606910 MGI: 1330841 HomoloGene: 8396

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • mitochondrion • membrane • integral to membrane
Biological Process:	• anti-apoptosis • caspase activation • spermatogenesis • female gamete generation • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020396 (mRNA)
NP_065129 (protein)

NM_013479 (mRNA)
NP_038507 (protein)

Location

Chr 15: 50.19 - 50.19 Mb

Chr 9: 75.13 - 75.14 Mb

Pubmed search

[1]

[2]

BCL2-like 10 (apoptosis facilitator), also known as BCL2L10, is a human gene.^[1]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator).

[edit] Further reading

van Oirschot JT (1999). "Diva vaccines that reduce virus transmission.". J. Biotechnol. 73 (2-3): 195-205. PMID 10486928.
Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex.". J. Biol. Chem. 273 (10): 5841-5. PMID 9488720.
Inohara N, Gourley TS, Carrio R, et al. (1999). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death.". J. Biol. Chem. 273 (49): 32479-86. PMID 9829980.
Song Q, Kuang Y, Dixit VM, Vincenz C (1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1.". EMBO J. 18 (1): 167-78. doi:10.1093/emboj/18.1.167. PMID 9878060.
Ke N, Godzik A, Reed JC (2001). "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.". J. Biol. Chem. 276 (16): 12481-4. doi:10.1074/jbc.C000871200. PMID 11278245.
Naumann U, Weit S, Wischhusen J, Weller M (2001). "Diva/Boo is a negative regulator of cell death in human glioma cells.". FEBS Lett. 505 (1): 23-6. PMID 11557035.
Aouacheria A, Arnaud E, Venet S, et al. (2001). "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis.". Oncogene 20 (41): 5846-55. doi:10.1038/sj.onc.1204740. PMID 11593390.
Zhang H, Holzgreve W, De Geyter C (2002). "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway.". Hum. Mol. Genet. 10 (21): 2329-39. PMID 11689480.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma.". Int. J. Clin. Oncol. 8 (2): 83-9. doi:10.1007/s101470300015. PMID 12720100.
Kang Y, Lee DC, Han J, et al. (2007). "NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling.". Biochem. Biophys. Res. Commun. 359 (1): 76-82. doi:10.1016/j.bbrc.2007.05.090. PMID 17532299.