BCL2A1

From Wikipedia, the free encyclopedia

BCL2-related protein A1

Identifiers

BCL2A1; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1

External IDs

OMIM: 601056 MGI: 102687 HomoloGene: 2988

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• intracellular
Biological Process:	• anti-apoptosis • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004049 (mRNA)
NP_004040 (protein)

NM_009742 (mRNA)
NP_033872 (protein)

Location

Chr 15: 78.04 - 78.05 Mb

Chr 9: 88.75 - 88.76 Mb

Pubmed search

[1]

[2]

BCL2-related protein A1, also known as BCL2A1, is a human gene.^[1]

This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCL2A1 BCL2-related protein A1.

[edit] Further reading

Choi SS, Park IC, Yun JW, et al. (1995). "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.". Oncogene 11 (9): 1693–8. PMID 7478596.
Lin EY, Orlofsky A, Berger MS, Prystowsky MB (1993). "Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.". J. Immunol. 151 (4): 1979–88. PMID 8345191.
Savitsky K, Sfez S, Tagle DA, et al. (1996). "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.". Hum. Mol. Genet. 4 (11): 2025–32. PMID 8589678.
Karsan A, Yee E, Kaushansky K, Harlan JM (1996). "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.". Blood 87 (8): 3089–96. PMID 8605321.
Karsan A, Yee E, Harlan JM (1996). "Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1.". J. Biol. Chem. 271 (44): 27201–4. PMID 8910286.
Carrió R, López-Hoyos M, Jimeno J, et al. (1997). "A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death.". Am. J. Pathol. 149 (6): 2133–42. PMID 8952545.
Kenny JJ, Knobloch TJ, Augustus M, et al. (1997). "GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes.". Oncogene 14 (8): 997–1001. doi:10.1038/sj.onc.1200898. PMID 9050999.
Choi SS, Park SH, Kim UJ, Shin HS (1997). "Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3.". Mamm. Genome 8 (10): 781–2. PMID 9321477.
Hsu SY, Kaipia A, McGee E, et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. PMID 9356461.
Takemoto Y, Furuta M, Sato M, et al. (1998). "Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.". J. Immunol. 161 (2): 625–30. PMID 9670936.
Zong WX, Edelstein LC, Chen C, et al. (1999). "The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis.". Genes Dev. 13 (4): 382–7. PMID 10049353.
Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members.". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646.
Lee HH, Dadgostar H, Cheng Q, et al. (1999). "NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9136–41. PMID 10430908.
Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999). "NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis.". Mol. Cell. Biol. 19 (9): 5923–9. PMID 10454539.
Tomayko MM, Punt JA, Bolcavage JM, et al. (1999). "Expression of the Bcl-2 family member A1 is developmentally regulated in T cells.". Int. Immunol. 11 (11): 1753–61. PMID 10545479.
Zhang H, Cowan-Jacob SW, Simonen M, et al. (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells.". J. Biol. Chem. 275 (15): 11092–9. PMID 10753914.
Duriez PJ, Wong F, Dorovini-Zis K, et al. (2000). "A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor.". J. Biol. Chem. 275 (24): 18099–107. doi:10.1074/jbc.M908925199. PMID 10849436.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Bae J, Hsu SY, Leo CP, et al. (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.". Apoptosis 6 (5): 319–30. PMID 11483855.
Akari H, Bour S, Kao S, et al. (2001). "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors.". J. Exp. Med. 194 (9): 1299–311. PMID 11696595.