BCL2-like 1 (gene)

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BCL2-like 1

PDB rendering based on 1af3.

Available structures: 1af3, 1bxl, 1lxl, 1maz, 1pq0, 1pq1, 1r2d, 1r2e, 1r2g, 1r2h, 1r2i, 2b48, 2bzw

Identifiers

Symbol(s)

BCL2L1; BCL-XL/S; BCL2L; BCLX; Bcl-X; DKFZp781P2092; bcl-xL; bcl-xS

External IDs

OMIM: 600039 MGI: 88139 HomoloGene: 7639

Gene ontology
Molecular Function:	• identical protein binding
Cellular Component:	• nucleus • mitochondrion • mitochondrial outer membrane • membrane • integral to membrane
Biological Process:	• anti-apoptosis • negative regulation of survival gene product activity • apoptotic mitochondrial changes • response to radiation • regulation of apoptosis • positive regulation of anti-apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001191 (mRNA)
NP_001182 (protein)

NM_009743 (mRNA)
NP_033873 (protein)

Location

Chr 20: 29.72 - 29.77 Mb

Chr 2: 152.46 - 152.52 Mb

Pubmed search

[1]

[2]

BCL2-like 1, also known as BCL2L1, is a human gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.^[1]