BCL11B

From Wikipedia, the free encyclopedia


B-cell CLL/lymphoma 11B (zinc finger protein)
Identifiers
Symbol(s) BCL11B; RIT1; CTIP-2; CTIP2; hRIT1-alpha
External IDs OMIM: 606558 MGI: 1929913 HomoloGene: 10974
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 64919 58208
Ensembl ENSG00000127152 ENSMUSG00000048251
Uniprot Q9C0K0 Q3TEG9
Refseq NM_022898 (mRNA)
NP_075049 (protein)		 NM_001079883 (mRNA)
NP_001073352 (protein)
Location Chr 14: 98.71 - 98.81 Mb Chr 12: 108.36 - 108.45 Mb
Pubmed search [1] [2]

B-cell CLL/lymphoma 11B (zinc finger protein), also known as BCL11B, is a human gene.[1]

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein).

[edit] Further reading

  • Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.". J. Biol. Chem. 275 (14): 10315-22. PMID 10744719. 
  • Satterwhite E, Sonoki T, Willis TG, et al. (2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies.". Blood 98 (12): 3413-20. PMID 11719382. 
  • Avram D, Fields A, Senawong T, et al. (2003). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.". Biochem. J. 368 (Pt 2): 555-63. doi:10.1042/BJ20020496. PMID 12196208. 
  • Wakabayashi Y, Inoue J, Takahashi Y, et al. (2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas.". Biochem. Biophys. Res. Commun. 301 (2): 598-603. PMID 12565905. 
  • Rohr O, Lecestre D, Chasserot-Golaz S, et al. (2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells.". J. Virol. 77 (9): 5415-27. PMID 12692243. 
  • Senawong T, Peterson VJ, Avram D, et al. (2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.". J. Biol. Chem. 278 (44): 43041-50. doi:10.1074/jbc.M307477200. PMID 12930829. 
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, et al. (2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.". Cancer Genet. Cytogenet. 149 (1): 72-6. PMID 15104287. 
  • MacLeod RA, Nagel S, Drexler HG (2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia.". Cancer Genet. Cytogenet. 153 (1): 88-9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104. 
  • Przybylski GK, Dik WA, Wanzeck J, et al. (2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL.". Leukemia 19 (2): 201-8. doi:10.1038/sj.leu.2403619. PMID 15668700. 
  • Cismasiu VB, Adamo K, Gecewicz J, et al. (2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter.". Oncogene 24 (45): 6753-64. doi:10.1038/sj.onc.1208904. PMID 16091750. 
  • Topark-Ngarm A, Golonzhka O, Peterson VJ, et al. (2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene.". J. Biol. Chem. 281 (43): 32272-83. doi:10.1074/jbc.M602776200. PMID 16950772. 
  • Marban C, Suzanne S, Dequiedt F, et al. (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.". EMBO J. 26 (2): 412-23. doi:10.1038/sj.emboj.7601516. PMID 17245431. 
  • Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.". Cancer Res. 67 (4): 1461-71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084. 
  • Kamimura K, Mishima Y, Obata M, et al. (2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages.". Oncogene 26 (40): 5840-50. doi:10.1038/sj.onc.1210388. PMID 17369851. 

[edit] External links


 This article on a gene on chromosome 14 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD