BCL10

From Wikipedia, the free encyclopedia

B-cell CLL/lymphoma 10

Identifiers

BCL10; CARMEN; CIPER; CLAP; c-E10; mE10

External IDs

OMIM: 603517 MGI: 1337994 HomoloGene: 2912

Gene ontology
Molecular Function:	• transcription coactivator activity • protein C-terminus binding • kinase activator activity • ubiquitin protein ligase binding • ubiquitin binding • protein kinase B binding • protein self-association • NF-kappaB binding
Cellular Component:	• intracellular • nucleus • cytoplasm • lysosome • cytosol • CBM complex • T cell receptor complex • lipid raft • lipopolysaccharide receptor complex • perinuclear region of cytoplasm
Biological Process:	• toll-like receptor signaling pathway • response to molecule of bacterial origin • adaptive immune response • negative regulation of mature B cell apoptosis • cell cycle • I-kappaB kinase/NF-kappaB cascade • cell death • immunoglobulin mediated immune response • positive regulation of protein ubiquitination • positive regulation of mast cell cytokine production • lymphotoxin A biosynthetic process • response to chemical stimulus • interleukin-6 biosynthetic process • positive regulation of phosphorylation • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • innate immune response • positive regulation of interleukin-8 biosynthetic process • negative regulation of progression through cell cycle • positive regulation of transcription, DNA-dependent • T cell receptor signaling pathway • activation of NF-kappaB transcription factor • protein homooligomerization

Orthologs

Human

Mouse

Entrez

8915

12042

Refseq

NM_003921 (mRNA)
NP_003912 (protein)

NM_009740 (mRNA)
NP_033870 (protein)

Pubmed search

[1]

[2]

B-cell CLL/lymphoma 10, also known as BCL10, is a human gene.^[1]

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCL10 B-cell CLL/lymphoma 10.

[edit] Further reading

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma.". Hematol. J. 3 (1): 10-3. doi:10.1038/sj/thj/6200146. PMID 11960389.
Lee WC, Balsara B, Liu Z, et al. (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma.". Cancer Res. 56 (19): 4297-301. PMID 8813110.
Willis TG, Jadayel DM, Du MQ, et al. (1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.". Cell 96 (1): 35-45. PMID 9989495.
Koseki T, Inohara N, Chen S, et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.". J. Biol. Chem. 274 (15): 9955-61. PMID 10187770.
Thome M, Martinon F, Hofmann K, et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.". J. Biol. Chem. 274 (15): 9962-8. PMID 10187771.
Yan M, Lee J, Schilbach S, et al. (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule.". J. Biol. Chem. 274 (15): 10287-92. PMID 10187815.
Zhang Q, Siebert R, Yan M, et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).". Nat. Genet. 22 (1): 63-8. doi:10.1038/8767. PMID 10319863.
Srinivasula SM, Ahmad M, Lin JH, et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.". J. Biol. Chem. 274 (25): 17946-54. PMID 10364242.
Apostolou S, De Rienzo A, Murthy SS, et al. (1999). "Absence of BCL10 mutations in human malignant mesothelioma.". Cell 97 (6): 684-6; discussion 686-8. PMID 10380921.
Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.". J. Biol. Chem. 274 (29): 20127-32. PMID 10400625.
Yoneda T, Imaizumi K, Maeda M, et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.". J. Biol. Chem. 275 (15): 11114-20. PMID 10753917.
Ye H, Dogan A, Karran L, et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.". Am. J. Pathol. 157 (4): 1147-54. PMID 11021819.
Bertin J, Guo Y, Wang L, et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.". J. Biol. Chem. 275 (52): 41082-6. doi:10.1074/jbc.C000726200. PMID 11053425.
Uren AG, O'Rourke K, Aravind LA, et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.". Mol. Cell 6 (4): 961-7. PMID 11090634.
Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.". J. Biol. Chem. 276 (5): 3183-7. doi:10.1074/jbc.C000792200. PMID 11113112.
Ruland J, Duncan GS, Elia A, et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.". Cell 104 (1): 33-42. PMID 11163238.
Wang L, Guo Y, Huang WJ, et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405-9. doi:10.1074/jbc.M102488200. PMID 11259443.
Lucas PC, Yonezumi M, Inohara N, et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.". J. Biol. Chem. 276 (22): 19012-9. doi:10.1074/jbc.M009984200. PMID 11262391.
Bertin J, Wang L, Guo Y, et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.". J. Biol. Chem. 276 (15): 11877-82. doi:10.1074/jbc.M010512200. PMID 11278692.
Gaide O, Martinon F, Micheau O, et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.". FEBS Lett. 496 (2-3): 121-7. PMID 11356195.