BCKDK

From Wikipedia, the free encyclopedia

Branched chain ketoacid dehydrogenase kinase

PDB rendering based on 1gjv.

Available structures: 1gjv, 1gkx, 1gkz

Identifiers

Symbol(s)

BCKDK;

External IDs

MGI: 1276121 HomoloGene: 37642

Gene ontology
Molecular Function:	• nucleotide binding • protein histidine kinase activity • ATP binding
Cellular Component:	• mitochondrion • mitochondrial alpha-ketoglutarate dehydrogenase complex
Biological Process:	• branched chain family amino acid catabolic process • phosphorylation • peptidyl-histidine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005881 (mRNA)
NP_005872 (protein)

NM_009739 (mRNA)
NP_033869 (protein)

Location

Chr 16: 31.03 - 31.03 Mb

Chr 7: 127.7 - 127.7 Mb

Pubmed search

[1]

[2]

Branched chain ketoacid dehydrogenase kinase, also known as BCKDK, is a human gene.^[1]

[edit] References

^ Entrez Gene: BCKDK branched chain ketoacid dehydrogenase kinase.

[edit] Further reading

Popov KM, Zhao Y, Shimomura Y, et al. (1992). "Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases.". J. Biol. Chem. 267 (19): 13127–30. PMID 1377677.
Zneimer SM, Lau KS, Eddy RL, et al. (1991). "Regional assignment of two genes of the human branched-chain alpha-keto acid dehydrogenase complex: the E1 beta gene (BCKDHB) to chromosome 6p21-22 and the E2 gene (DBT) to chromosome 1p31.". Genomics 10 (3): 740–7. PMID 1889817.
Chang CF, Chou HT, Chuang JL, et al. (2002). "Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex.". J. Biol. Chem. 277 (18): 15865–73. doi:10.1074/jbc.M110952200. PMID 11839747.
Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Starcevic M, Dell'Angelica EC (2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).". J. Biol. Chem. 279 (27): 28393–401. doi:10.1074/jbc.M402513200. PMID 15102850.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wynn RM, Kato M, Machius M, et al. (2005). "Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation.". Structure 12 (12): 2185–96. doi:10.1016/j.str.2004.09.013. PMID 15576032.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.