BCGF1

From Wikipedia, the free encyclopedia

B-cell growth factor 1, 12kDa

Identifiers

External IDs

Gene ontology
Molecular Function:	• growth factor activity
Cellular Component:	• extracellular region
Biological Process:	• humoral immune response • signal transduction • positive regulation of cell proliferation

Orthologs

Human

Mouse

Entrez

588

n/a

Pubmed search

[1]

n/a

B-cell growth factor 1, 12kDa, also known as BCGF1, is a human gene.^[1]

B-cell growth factor is released by T lymphocytes after either lectin or antigen stimulation. It supports the clonal proliferation of B lymphocytes.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCGF1 B-cell growth factor 1, 12kDa.

[edit] Further reading

Kumar A, Vasquez A, Maizel AL, Sharma S (1991). "Human BCGF-12kD functions as an autocrine growth factor in transformed B cells.". Eur. Cytokine Netw. 1 (2): 109–13. PMID 1966378.
Vazquez A, Mills S, Sharma S, Maizel AL (1988). "Expression of CD23 antigen is not necessary for human 12-kDa B cell growth factor-mediated B cell proliferation.". Eur. J. Immunol. 18 (10): 1647–9. PMID 2973416.
Mehta SR, Sandler RS, Ford RJ, et al. (1986). "Cellular interaction between B and T lymphocytes: enhanced release of B cell growth factor.". Lymphokine Res. 5 (1): 49–57. PMID 3484798.
Ennist DL, Greenblatt D, Coffman R, et al. (1987). "Activity of a partially purified human BCGF on murine assays for B-cell stimulatory factors. I. BCGF II-like activity of human BCGF.". Cell. Immunol. 110 (1): 77–94. PMID 3499989.
Sharma S, Mehta S, Morgan J, Maizel A (1987). "Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli.". Science 235 (4795): 1489–92. PMID 3547651.
Sahasrabuddhe CG, Morgan J, Sharma S, et al. (1985). "Evidence for an intracellular precursor for human B-cell growth factor.". Proc. Natl. Acad. Sci. U.S.A. 81 (24): 7902–6. PMID 6083564.
Kovanen PE, Virtaneva K, Harju L, et al. (1995). "Expression and characterization of a B cell growth promoting polypeptide derived from the 12 kDa B cell growth factor gene (BCGF 1).". FEBS Lett. 361 (2-3): 233–7. PMID 7698329.
Zietkiewicz E, Makałowski W, Mitchell GA, Labuda D (1994). "Phylogenetic analysis of a reported complementary DNA sequence.". Science 265 (5175): 1110–1. PMID 8066452.
Kovanen PE, Harju L, Timonen T (1996). "Complementary DNA for 12-kilodalton B cell growth factor: misassigned.". Science 274 (5287): 629–31. PMID 8928011.
Zietkiewicz E, Makałowski W, Mitchell G, Labuda D (1996). "Complementary DNA for 12-kilodalton B cell growth factor: misassigned.". Science 274 (5287): 631; author reply 631. PMID 8928012.