BCAR3

From Wikipedia, the free encyclopedia

Breast cancer anti-estrogen resistance 3

Identifiers

BCAR3; NSP2; KIAA0554; SH2D3B

External IDs

OMIM: 604704 MGI: 1352501 HomoloGene: 31181

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of progression through cell cycle • small GTPase mediated signal transduction • response to drug

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003567 (mRNA)
NP_003558 (protein)

NM_013867 (mRNA)
NP_038895 (protein)

Location

Chr 1: 93.8 - 94.09 Mb

Chr 3: 122.41 - 122.52 Mb

Pubmed search

[1]

[2]

Breast cancer anti-estrogen resistance 3, also known as BCAR3, is a human gene.^[1]

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.^[1]

[edit] References

^ ^a ^b Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3.

[edit] Further reading

Dorssers LC, van Agthoven T (1997). "Genetic mechanisms of estrogen-independence in breast cancer.". Pathol. Res. Pract. 192 (7): 743–51. PMID 8880875.
Johnston SR (1998). "Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications.". Anticancer Drugs 8 (10): 911–30. PMID 9436634.
van Agthoven T, van Agthoven TL, Dekker A, et al. (1998). "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.". EMBO J. 17 (10): 2799–808. doi:10.1093/emboj/17.10.2799. PMID 9582273.
Lu Y, Brush J, Stewart TA (1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway.". J. Biol. Chem. 274 (15): 10047–52. PMID 10187783.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cai D, Felekkis KN, Near RI, et al. (2003). "The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.". J. Immunol. 170 (2): 969–78. PMID 12517963.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dorssers LC, van Agthoven T, Brinkman A, et al. (2006). "Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway.". Breast Cancer Res. 7 (1): R82–92. doi:10.1186/bcr954. PMID 15642172.
Felekkis KN, Narsimhan RP, Near R, et al. (2005). "AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.". Mol. Cancer Res. 3 (1): 32–41. PMID 15671247.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Vervoort VS, Roselli S, Oshima RG, Pasquale EB (2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.". Gene 391 (1-2): 161–70. doi:10.1016/j.gene.2006.12.016. PMID 17270363.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Near RI, Zhang Y, Makkinje A, et al. (2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059. PMID 17427198.
Schrecengost RS, Riggins RB, Thomas KS, et al. (2007). "Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling.". Cancer Res. 67 (13): 6174–82. doi:10.1158/0008-5472.CAN-06-3455. PMID 17616674.