BCAR1

From Wikipedia, the free encyclopedia

Breast cancer anti-estrogen resistance 1

PDB rendering based on 1wyx.

Available structures: 1wyx

Identifiers

Symbol(s)

BCAR1; CAS; CRKAS; P130Cas

External IDs

OMIM: 602941 MGI: 108091 HomoloGene: 7674

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • protein kinase binding • protein phosphatase binding
Cellular Component:	• ruffle • membrane fraction • cytoplasm • focal adhesion
Biological Process:	• regulation of cell growth • actin filament organization • epidermal growth factor receptor signaling pathway • G-protein coupled receptor protein signaling pathway • integrin-mediated signaling pathway • cell proliferation • insulin receptor signaling pathway • cell migration • positive regulation of cell migration • regulation of apoptosis • platelet-derived growth factor receptor signaling pathway • nerve growth factor receptor signaling pathway • T cell receptor signaling pathway • B cell receptor signaling pathway • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014567 (mRNA)
NP_055382 (protein)

NM_009954 (mRNA)
NP_034084 (protein)

Location

Chr 16: 73.82 - 73.84 Mb

Chr 8: 114.6 - 114.61 Mb

Pubmed search

[1]

[2]

Breast cancer anti-estrogen resistance 1, also known as BCAR1, is a human gene.

[edit] Further reading

Rozengurt E (1999). "Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists.". J. Cell. Physiol. 177 (4): 507–17. doi:10.1002/(SICI)1097-4652(199812)177:4<507::AID-JCP2>3.0.CO;2-K. PMID 10092204.
O'Neill GM, Fashena SJ, Golemis EA (2000). "Integrin signalling: a new Cas(t) of characters enters the stage.". Trends Cell Biol. 10 (3): 111–9. PMID 10675905.
Bouton AH, Riggins RB, Bruce-Staskal PJ (2001). "Functions of the adapter protein Cas: signal convergence and the determination of cellular responses.". Oncogene 20 (44): 6448–58. doi:10.1038/sj.onc.1204785. PMID 11607844.
Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.". Front. Biosci. 7: d143–50. PMID 11779709.
Mayer BJ, Hirai H, Sakai R (1995). "Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.". Curr. Biol. 5 (3): 296–305. PMID 7780740.
Sakai R, Iwamatsu A, Hirano N, et al. (1994). "A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.". EMBO J. 13 (16): 3748–56. PMID 8070403.
Dorssers LC, van Agthoven T, Dekker A, et al. (1993). "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.". Mol. Endocrinol. 7 (7): 870–8. PMID 8413311.
Vuori K, Hirai H, Aizawa S, Ruoslahti E (1996). "Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.". Mol. Cell. Biol. 16 (6): 2606–13. PMID 8649368.
Law SF, Estojak J, Wang B, et al. (1996). "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.". Mol. Cell. Biol. 16 (7): 3327–37. PMID 8668148.
Khwaja A, Hallberg B, Warne PH, Downward J (1996). "Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.". Oncogene 12 (12): 2491–8. PMID 8700507.
Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.". J. Biol. Chem. 271 (41): 25198–203. PMID 8810278.
Garton AJ, Flint AJ, Tonks NK (1996). "Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.". Mol. Cell. Biol. 16 (11): 6408–18. PMID 8887669.
Liu F, Hill DE, Chernoff J (1997). "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).". J. Biol. Chem. 271 (49): 31290–5. PMID 8940134.
Astier A, Avraham H, Manie SN, et al. (1997). "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas.". J. Biol. Chem. 272 (1): 228–32. PMID 8995252.
Jücker M, McKenna K, da Silva AJ, et al. (1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling.". J. Biol. Chem. 272 (4): 2104–9. PMID 8999909.
Manié SN, Beck AR, Astier A, et al. (1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.". J. Biol. Chem. 272 (7): 4230–6. PMID 9020138.
Schlaepfer DD, Hunter T (1997). "Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.". J. Biol. Chem. 272 (20): 13189–95. PMID 9148935.
Manié SN, Astier A, Haghayeghi N, et al. (1997). "Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2.". J. Biol. Chem. 272 (25): 15636–41. PMID 9188452.
Garton AJ, Burnham MR, Bouton AH, Tonks NK (1997). "Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition.". Oncogene 15 (8): 877–85. doi:10.1038/sj.onc.1201279. PMID 9285683.
Kanda H, Mimura T, Morino N, et al. (1997). "Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk.". Eur. J. Immunol. 27 (8): 2113–7. PMID 9295052.