BCAN

From Wikipedia, the free encyclopedia

Brevican

Identifiers

BCAN; BEHAB; CSPG7; MGC13038

External IDs

OMIM: 600347 MGI: 1096385 HomoloGene: 7244

Gene ontology
Molecular Function:	• sugar binding • hyaluronic acid binding • GPI anchor binding
Cellular Component:	• membrane
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021948 (mRNA)
NP_068767 (protein)

NM_007529 (mRNA)
NP_031555 (protein)

Location

Chr 1: 154.88 - 154.9 Mb

Chr 3: 88.07 - 88.09 Mb

Pubmed search

[1]

[2]

Brevican, also known as BCAN, is a human gene.^[1]

[edit] References

^ Entrez Gene: BCAN brevican.

[edit] Further reading

Seidenbecher CI, Richter K, Rauch U, et al. (1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms.". J. Biol. Chem. 270 (45): 27206–12. PMID 7592978.
Aspberg A, Miura R, Bourdoulous S, et al. (1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10116–21. PMID 9294172.
Nakamura H, Fujii Y, Inoki I, et al. (2001). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.". J. Biol. Chem. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
Olin AI, Mörgelin M, Sasaki T, et al. (2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.". J. Biol. Chem. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
Gary SC, Zerillo CA, Chiang VL, et al. (2001). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma.". Gene 256 (1-2): 139–47. PMID 11054543.
Nomoto H, Oohashi T, Hirakawa S, et al. (2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.". Acta Med. Okayama 56 (1): 25–9. PMID 11873941.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Xu XM, Chen Y, Chen J, et al. (2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis.". Cancer Res. 63 (18): 5685–90. PMID 14522884.
Bekku Y, Su WD, Hirakawa S, et al. (2004). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.". Mol. Cell. Neurosci. 24 (1): 148–59. PMID 14550776.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dong Y, Han X, Xue Y, et al. (2004). "Secreted brevican mRNA is expressed in the adult rat pituitary.". Biochem. Biophys. Res. Commun. 314 (3): 745–8. PMID 14741698.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Viapiano MS, Bi WL, Piepmeier J, et al. (2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.". Cancer Res. 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
Nakada M, Miyamori H, Kita D, et al. (2007). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican.". Acta Neuropathol. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.