BAP1

From Wikipedia, the free encyclopedia

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Identifiers

BAP1; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP-13; KIAA0272; hucep-6

External IDs

OMIM: 603089 MGI: 1206586 HomoloGene: 3421

Gene ontology
Molecular Function:	• ubiquitin thiolesterase activity • protein binding • cysteine-type peptidase activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004656 (mRNA)
NP_004647 (protein)

NM_027088 (mRNA)
NP_081364 (protein)

Location

Chr 3: 52.41 - 52.42 Mb

Chr 14: 30.08 - 30.09 Mb

Pubmed search

[1]

[2]

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), also known as BAP1, is a human gene.^[1]

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase).

[edit] Further reading

Jensen DE, Rauscher FJ (1999). "Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1.". Cancer Lett. 143 Suppl 1: S13-7. PMID 10546591.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321-9, 341-54. PMID 9039502.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Jensen DE, Proctor M, Marquis ST, et al. (1998). "BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.". Oncogene 16 (9): 1097-112. PMID 9528852.
Castegna A, Aksenov M, Aksenova M, et al. (2003). "Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.". Free Radic. Biol. Med. 33 (4): 562-71. PMID 12160938.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.". Int. J. Cancer 106 (2): 244-51. doi:10.1002/ijc.11208. PMID 12800201.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.