BAG5

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BCL2-associated athanogene 5
PDB rendering based on 1ugo.
Available structures: 1ugo, 2d9d
Identifiers
Symbol(s) BAG5; BAG-5
External IDs OMIM: 603885 MGI: 1917619 HomoloGene: 3584
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9529 70369
Ensembl ENSG00000166170 ENSMUSG00000049792
Uniprot Q9UL15 Q8CI32
Refseq NM_001015048 (mRNA)
NP_001015048 (protein)		 XM_987800 (mRNA)
XP_992894 (protein)
Location Chr 14: 103.09 - 103.1 Mb Chr 12: 112.16 - 112.16 Mb
Pubmed search [1] [2]

BCL2-associated athanogene 5, also known as BAG5, is a human gene.[1]

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: BAG5 BCL2-associated athanogene 5.

[edit] Further reading

  • Takayama S, Sato T, Krajewski S, et al. (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity.". Cell 80 (2): 279–84. PMID 7834747. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Höhfeld J, Jentsch S (1997). "GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1.". EMBO J. 16 (20): 6209–16. doi:10.1093/emboj/16.20.6209. PMID 9321400. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. PMID 9873016. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kalia SK, Lee S, Smith PD, et al. (2005). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.". Neuron 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737. 
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