BAG3

From Wikipedia, the free encyclopedia

BCL2-associated athanogene 3

PDB rendering based on 1uk5.

Available structures: 1uk5

Identifiers

Symbol(s)

BAG3; BAG-3; BIS; CAIR-1; MGC104307

External IDs

OMIM: 603883 MGI: 1352493 HomoloGene: 3162

Gene ontology
Molecular Function:	• protein binding • Hsp70/Hsc70 protein regulator activity
Cellular Component:	• cellular_component • cytosol
Biological Process:	• protein folding • apoptosis • anti-apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004281 (mRNA)
NP_004272 (protein)

NM_013863 (mRNA)
NP_038891 (protein)

Location

Chr 10: 121.4 - 121.43 Mb

Chr 7: 128.31 - 128.34 Mb

Pubmed search

[1]

[2]

BCL2-associated athanogene 3, also known as BAG3, is a human gene.^[1]

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.^[1]

[edit] References

^ ^a ^b Entrez Gene: BAG3 BCL2-associated athanogene 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. PMID 9873016.
Lee JH, Takahashi T, Yasuhara N, et al. (2000). "Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.". Oncogene 18 (46): 6183–90. doi:10.1038/sj.onc.1203043. PMID 10597216.
Doong H, Price J, Kim YS, et al. (2000). "CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70.". Oncogene 19 (38): 4385–95. doi:10.1038/sj.onc.1203797. PMID 10980614.
Liao Q, Ozawa F, Friess H, et al. (2001). "The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines.". FEBS Lett. 503 (2-3): 151–7. PMID 11513873.
Antoku K, Maser RS, Scully WJ, et al. (2001). "Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.". Biochem. Biophys. Res. Commun. 286 (5): 1003–10. doi:10.1006/bbrc.2001.5512. PMID 11527400.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Romano MF, Festa M, Pagliuca G, et al. (2003). "BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis.". Cell Death Differ. 10 (3): 383–5. doi:10.1038/sj.cdd.4401167. PMID 12700638.
Pagliuca MG, Lerose R, Cigliano S, Leone A (2003). "Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity.". FEBS Lett. 541 (1-3): 11–5. PMID 12706811.
Doong H, Rizzo K, Fang S, et al. (2003). "CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.". J. Biol. Chem. 278 (31): 28490–500. doi:10.1074/jbc.M209682200. PMID 12750378.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Seo YJ, Jeon MH, Lee JH, et al. (2006). "Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27.". Exp. Mol. Med. 37 (6): 624–30. PMID 16391524.
Kassis JN, Guancial EA, Doong H, et al. (2006). "CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins.". Exp. Cell Res. 312 (15): 2962–71. doi:10.1016/j.yexcr.2006.05.023. PMID 16859681.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.