BAG1
From Wikipedia, the free encyclopedia
BCL2-associated athanogene
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PDB rendering based on 1hx1. | ||||||||||||||
Available structures: 1hx1, 1wxv | ||||||||||||||
Identifiers | ||||||||||||||
Symbol(s) | BAG1; | |||||||||||||
External IDs | OMIM: 601497 MGI: 108047 HomoloGene: 3190 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 573 | 12017 | ||||||||||||
Ensembl | ENSG00000107262 | ENSMUSG00000028416 | ||||||||||||
Uniprot | Q99933 | Q6IS45 | ||||||||||||
Refseq | NM_004323 (mRNA) NP_004314 (protein) |
NM_009736 (mRNA) NP_033866 (protein) |
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Location | Chr 9: 33.24 - 33.25 Mb | Chr 4: 41.13 - 41.14 Mb | ||||||||||||
Pubmed search | [1] | [2] |
BCL2-associated athanogene, also known as BAG1, is a human gene.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[1]
[edit] References
[edit] Further reading
- Tang SC (2003). "BAG-1, an anti-apoptotic tumour marker.". IUBMB Life 53 (2): 99–105. PMID 12049201.
- Clemo NK, Arhel NJ, Barnes JD, et al. (2005). "The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.". Biochem. Soc. Trans. 33 (Pt 4): 676–8. doi: . PMID 16042572.
- Gehring U (2007). "Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms.". Cell Stress Chaperones 11 (4): 295–303. PMID 17278878.
- Takayama S, Sato T, Krajewski S, et al. (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity.". Cell 80 (2): 279–84. PMID 7834747.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Zeiner M, Gehring U (1996). "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11465–9. PMID 8524784.
- Wang HG, Takayama S, Rapp UR, Reed JC (1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. PMID 8692945.
- Takayama S, Kochel K, Irie S, et al. (1996). "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.". Genomics 35 (3): 494–8. doi: . PMID 8812483.
- Bardelli A, Longati P, Albero D, et al. (1997). "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.". EMBO J. 15 (22): 6205–12. PMID 8947043.
- Takayama S, Bimston DN, Matsuzawa S, et al. (1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70.". EMBO J. 16 (16): 4887–96. doi: . PMID 9305631.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
- Packham G, Brimmell M, Cleveland JL (1998). "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.". Biochem. J. 328 ( Pt 3): 807–13. PMID 9396724.
- Matsuzawa S, Takayama S, Froesch BA, et al. (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.". EMBO J. 17 (10): 2736–47. doi: . PMID 9582267.
- Kullmann M, Schneikert J, Moll J, et al. (1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis.". J. Biol. Chem. 273 (23): 14620–5. PMID 9603979.
- Liu R, Takayama S, Zheng Y, et al. (1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.". J. Biol. Chem. 273 (27): 16985–92. PMID 9642262.
- Takayama S, Krajewski S, Krajewska M, et al. (1998). "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.". Cancer Res. 58 (14): 3116–31. PMID 9679980.
- Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. PMID 9873016.
- Yang X, Pater A, Tang SC (1999). "Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.". Oncogene 18 (32): 4546–53. doi: . PMID 10467399.
- Schneikert J, Hübner S, Martin E, Cato AC (1999). "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.". J. Cell Biol. 146 (5): 929–40. PMID 10477749.
- Lüders J, Demand J, Höhfeld J (2000). "The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.". J. Biol. Chem. 275 (7): 4613–7. PMID 10671488.