Bafilomycin (BAF)

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Bafilomycin is indeed a whole family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).

The most used Bafilomycin is Bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Bafilomycin has antibacterial, antifungal, antineoplastic, immunosuppressive activities. It has been shown to decrease multi-drug resistance.


Bafilomycin A1 data[1]

  1. CAS number: 88899-55-2
  2. Molecular Formula: C35H58O9
  3. Appearance: Yellow powder
  4. Molecular weight: 622.830


[edit] References

  1. ^ Source (with permission) Bafilomycin A1 product page from Fermentek
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