B4GALT4

From Wikipedia, the free encyclopedia

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4

Identifiers

B4GALT4; B4Gal-T4; beta4Gal-T4

External IDs

OMIM: 604015 MGI: 1928387 HomoloGene: 37848

Gene ontology
Molecular Function:	• N-acetyllactosamine synthase activity • galactosyltransferase activity • transferase activity, transferring glycosyl groups • manganese ion binding • metal ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• carbohydrate metabolic process • membrane lipid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003778 (mRNA)
NP_003769 (protein)

NM_019804 (mRNA)
NP_062778 (protein)

Location

Chr 3: 120.41 - 120.44 Mb

Chr 16: 38.66 - 38.69 Mb

Pubmed search

[1]

[2]

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4, also known as B4GALT4, is a human gene.^[1]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.

[edit] Further reading

Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.". Biochim. Biophys. Acta 1473 (1): 35–53. PMID 10580128.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.". AIDS Res. Hum. Retroviruses 6 (3): 371–80. PMID 2187500.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.". J. Virol. 63 (6): 2452–6. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.". AIDS Res. Hum. Retroviruses 3 (3): 265–82. PMID 2829950.
Lo NW, Shaper JH, Pevsner J, Shaper NL (1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks.". Glycobiology 8 (5): 517–26. PMID 9597550.
Schwientek T, Almeida R, Levery SB, et al. (1998). "Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.". J. Biol. Chem. 273 (45): 29331–40. PMID 9792633.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.
Guo S, Sato T, Shirane K, Furukawa K (2002). "Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.". Glycobiology 11 (10): 813–20. PMID 11588157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.