B4GALNT1

From Wikipedia, the free encyclopedia

Beta-1,4-N-acetyl-galactosaminyl transferase 1

Identifiers

B4GALNT1; GALGT; GALNACT

External IDs

OMIM: 601873 MGI: 1342057 HomoloGene: 1133

Gene ontology
Molecular Function:	• (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity • transferase activity • transferase activity, transferring hexosyl groups
Cellular Component:	• membrane fraction • membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• ganglioside biosynthetic process • carbohydrate metabolic process • glycosphingolipid metabolic process • sequestering of lipid • lipid glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001478 (mRNA)
NP_001469 (protein)

NM_008080 (mRNA)
NP_032106 (protein)

Location

Chr 12: 56.3 - 56.31 Mb

Chr 10: 126.57 - 126.58 Mb

Pubmed search

[1]

[2]

Beta-1,4-N-acetyl-galactosaminyl transferase 1, also known as B4GALNT1, is a human gene.^[1]

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.^[1]

[edit] References

^ ^a ^b Entrez Gene: B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1.

[edit] Further reading

Nagata Y, Yamashiro S, Yodoi J, et al. (1992). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides.". J. Biol. Chem. 267 (17): 12082–9. PMID 1601877.
Nagata Y, Yamashiro S, Yodoi J, et al. (1994). "Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides.". J. Biol. Chem. 269 (9): 7045. PMID 8120069.
Meurer JA, Naylor JM, Baker CA, et al. (1996). "cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase.". J. Biochem. 118 (3): 568–74. PMID 8690719.
Furukawa K, Soejima H, Niikawa N, Shiku H (1996). "Genomic organization and chromosomal assignment of the human beta1, 4-N-acetylgalactosaminyltransferase gene. Identification of multiple transcription units.". J. Biol. Chem. 271 (34): 20836–44. PMID 8702839.
Jaskiewicz E, Zhu G, Bassi R, et al. (1996). "Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease.". J. Biol. Chem. 271 (42): 26395–403. PMID 8824296.
Giraudo CG, Rosales Fritz VM, Maccioni HJ (1999). "GA2/GM2/GD2 synthase localizes to the trans-golgi network of CHO-K1 cells.". Biochem. J. 342 Pt 3: 633–40. PMID 10477274.
Toba S, Tenno M, Konishi M, et al. (2000). "Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9).". Biochim. Biophys. Acta 1493 (1-2): 264–8. PMID 10978536.
Li J, Yen TY, Allende ML, et al. (2001). "Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains.". J. Biol. Chem. 275 (52): 41476–86. doi:10.1074/jbc.M007480200. PMID 11018043.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.". Mol. Cell. Biochem. 298 (1-2): 59–68. doi:10.1007/s11010-006-9350-0. PMID 17119850.