B3GNT1

From Wikipedia, the free encyclopedia

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1

Identifiers

B3GNT1; B3GN-T1; B3GNT6; BETA3GNTI; iGAT; iGNT

External IDs

OMIM: 605517 MGI: 1919680 HomoloGene: 38239

Gene ontology
Molecular Function:	• N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• poly-N-acetyllactosamine biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006876 (mRNA)
NP_006867 (protein)

NM_175383 (mRNA)
NP_780592 (protein)

Location

Chr 11: 65.87 - 65.87 Mb

Chr 19: 5.04 - 5.04 Mb

Pubmed search

[1]

[2]

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, also known as B3GNT1, is a human gene.^[1]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen.^[1]

[edit] References

^ ^a ^b Entrez Gene: B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1.

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sasaki K, Kurata-Miura K, Ujita M, et al. (1998). "Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14294-9. PMID 9405606.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.