B-cell linker

From Wikipedia, the free encyclopedia

B-cell linker

Identifiers

BLNK; BASH; BLNK-s; Ly57; MGC111051; SLP-65; SLP65

External IDs

OMIM: 604515 MGI: 96878 HomoloGene: 32038

Gene ontology
Molecular Function:	• transmembrane receptor protein tyrosine kinase adaptor protein activity • SH3/SH2 adaptor activity • protein binding
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• inflammatory response • humoral immune response • intracellular signaling cascade • hemocyte development • B cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013314 (mRNA)
NP_037446 (protein)

NM_008528 (mRNA)
NP_032554 (protein)

Location

Chr 10: 97.94 - 98.02 Mb

Chr 19: 40.98 - 41.03 Mb

Pubmed search

[1]

[2]

B-cell linker, also known as BLNK, is a human gene.^[1]

Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: BLNK B-cell linker.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Fu C, Chan AC (1997). "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.". J. Biol. Chem. 272 (43): 27362–8. PMID 9341187.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Fu C, Turck CW, Kurosaki T, Chan AC (1998). "BLNK: a central linker protein in B cell activation.". Immunity 9 (1): 93–103. PMID 9697839.
Wienands J, Schweikert J, Wollscheid B, et al. (1998). "SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.". J. Exp. Med. 188 (4): 791–5. PMID 9705962.
Hashimoto S, Iwamatsu A, Ishiai M, et al. (1999). "Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.". Blood 94 (7): 2357–64. PMID 10498607.
Su YW, Zhang Y, Schweikert J, et al. (1999). "Interaction of SLP adaptors with the SH2 domain of Tec family kinases.". Eur. J. Immunol. 29 (11): 3702–11. PMID 10556826.
Minegishi Y, Rohrer J, Coustan-Smith E, et al. (1999). "An essential role for BLNK in human B cell development.". Science 286 (5446): 1954–7. PMID 10583958.
Fusaki N, Tomita S, Wu Y, et al. (2000). "BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking.". Eur. J. Immunol. 30 (5): 1326–30. PMID 10820378.
Mizuno K, Tagawa Y, Mitomo K, et al. (2000). "Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells.". J. Immunol. 165 (3): 1344–51. PMID 10903736.
Guo B, Kato RM, Garcia-Lloret M, et al. (2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.". Immunity 13 (2): 243–53. PMID 10981967.
Watanabe S, Take H, Takeda K, et al. (2001). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes.". Biochem. Biophys. Res. Commun. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
Tan JE, Wong SC, Gan SK, et al. (2001). "The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes.". J. Biol. Chem. 276 (23): 20055–63. doi:10.1074/jbc.M010800200. PMID 11274146.
Adachi T, Wienands J, Wakabayashi C, et al. (2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates.". J. Biol. Chem. 276 (28): 26648–55. doi:10.1074/jbc.M100997200. PMID 11356834.
Engels N, Wollscheid B, Wienands J (2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha.". Eur. J. Immunol. 31 (7): 2126–34. PMID 11449366.
Sauer K, Liou J, Singh SB, et al. (2002). "Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.". J. Biol. Chem. 276 (48): 45207–16. doi:10.1074/jbc.M106811200. PMID 11487585.
Engels N, Merchant M, Pappu R, et al. (2001). "Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module.". J. Exp. Med. 194 (3): 255–64. PMID 11489945.
Tsuji S, Okamoto M, Yamada K, et al. (2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.". J. Exp. Med. 194 (4): 529–39. PMID 11514608.
Kabak S, Skaggs BJ, Gold MR, et al. (2002). "The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.". Mol. Cell. Biol. 22 (8): 2524–35. PMID 11909947.
Yasuda T, Tezuka T, Maeda A, et al. (2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells.". J. Exp. Med. 196 (1): 51–63. PMID 12093870.