AZGP1

From Wikipedia, the free encyclopedia

Alpha-2-glycoprotein 1, zinc-binding

PDB rendering based on 1t7v.

Available structures: 1t7v, 1t7w, 1t7x, 1t7y, 1t7z, 1t80, 1zag, 2icn

Identifiers

Symbol(s)

AZGP1; ZA2G; ZAG

External IDs

OMIM: 194460 MGI: 103163 HomoloGene: 915

Gene ontology
Molecular Function:	• ribonuclease activity • fatty acid binding • protein carrier activity
Cellular Component:	• extracellular region • membrane • integral to membrane • MHC class I protein complex
Biological Process:	• antigen processing and presentation of peptide antigen via MHC class I • immune response • cell adhesion • negative regulation of cell proliferation • lipid catabolic process • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001185 (mRNA)
NP_001176 (protein)

NM_013478 (mRNA)
NP_038506 (protein)

Location

Chr 7: 99.4 - 99.41 Mb

Chr 5: 138.21 - 138.22 Mb

Pubmed search

[1]

[2]

Alpha-2-glycoprotein 1, zinc-binding, also known as AZGP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding.

[edit] Further reading

Freije JP, Fueyo A, Uría J, López-Otín C (1991). "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues.". FEBS Lett. 290 (1-2): 247–9. PMID 1915885.
Tada T, Ohkubo I, Niwa M, et al. (1991). "Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues.". J. Histochem. Cytochem. 39 (9): 1221–6. PMID 1918940.
Ueyama H, Niwa M, Tada T, et al. (1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene.". Biochem. Biophys. Res. Commun. 177 (2): 696–703. PMID 2049092.
Araki T, Gejyo F, Takagaki K, et al. (1988). "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens.". Proc. Natl. Acad. Sci. U.S.A. 85 (3): 679–83. PMID 3422450.
Shibata S, Miura K (1982). "Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine.". Nephron 31 (2): 170–6. PMID 6896906.
Ueyama H, Deng HX, Ohkubo I (1994). "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein.". Biochemistry 32 (48): 12968–76. PMID 8241150.
Freije JP, Fueyo A, Uría JA, et al. (1994). "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes.". Genomics 18 (3): 575–87. PMID 8307568.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Sánchez LM, López-Otín C, Bjorkman PJ (1997). "Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4626–30. PMID 9114041.
Brysk MM, Lei G, Rajaraman S, et al. (1997). "Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia.". In Vivo 11 (3): 271–4. PMID 9239523.
Lei G, Arany I, Selvanayagam P, et al. (1997). "Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors.". J. Cell. Biochem. 67 (2): 216–22. PMID 9328826.
Ogikubo O, Maeda T, Yamane T, et al. (1998). "Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives.". Biochem. Biophys. Res. Commun. 252 (1): 257–62. PMID 9813179.
Sánchez LM, Chirino AJ, Bjorkman P (1999). "Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.". Science 283 (5409): 1914–9. PMID 10206894.
Lei G, Brysk H, Arany I, et al. (1999). "Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line.". J. Cell. Biochem. 75 (1): 160–9. PMID 10462714.
Davidsson P, Nilsson CL (2000). "Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry.". Biochim. Biophys. Acta 1473 (2-3): 391–9. PMID 10594376.
Kennedy MW, Heikema AP, Cooper A, et al. (2001). "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins.". J. Biol. Chem. 276 (37): 35008–13. doi:10.1074/jbc.C100301200. PMID 11425849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
BURGI W, SCHMID K (1998). "Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma.". J. Biol. Chem. 236: 1066–74. PMID 13689030.