AXIN1

From Wikipedia, the free encyclopedia

Axin 1

PDB rendering based on 1dk8.

Available structures: 1dk8, 1emu, 1wsp, 2d5g

Identifiers

Symbol(s)

AXIN1; AXIN; MGC52315

External IDs

OMIM: 603816 MGI: 1096327 HomoloGene: 2614

Gene ontology
Molecular Function:	• signal transducer activity • protein binding
Cellular Component:	• intracellular • nucleus • cytoplasm • cytoplasmic membrane-bound vesicle • lateral plasma membrane
Biological Process:	• apoptosis • cell cycle • Wnt receptor signaling pathway • multicellular organismal development • oocyte axis determination • sensory perception of sound • protein catabolic process • negative regulation of Wnt receptor signaling pathway • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003502 (mRNA)
NP_003493 (protein)

XM_914907 (mRNA)
XP_920000 (protein)

Location

Chr 16: 0.28 - 0.34 Mb

Chr 17: 25.87 - 25.92 Mb

Pubmed search

[1]

[2]

Axin 1, also known as AXIN1, is a human gene.

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ Entrez Gene: AXIN1 axin 1.

[edit] Further reading

Segditsas S, Tomlinson I (2007). "Colorectal cancer and genetic alterations in the Wnt pathway.". Oncogene 25 (57): 7531–7. doi:10.1038/sj.onc.1210059. PMID 17143297.
Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region.". Nat. Genet. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID 9054936.
Zeng L, Fagotto F, Zhang T, et al. (1997). "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.". Cell 90 (1): 181–92. PMID 9230313.
Ikeda S, Kishida S, Yamamoto H, et al. (1998). "Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.". EMBO J. 17 (5): 1371–84. doi:10.1093/emboj/17.5.1371. PMID 9482734.
Hart MJ, de los Santos R, Albert IN, et al. (1998). "Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.". Curr. Biol. 8 (10): 573–81. PMID 9601641.
Nakamura T, Hamada F, Ishidate T, et al. (1998). "Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.". Genes Cells 3 (6): 395–403. PMID 9734785.
Hsu W, Zeng L, Costantini F (1999). "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.". J. Biol. Chem. 274 (6): 3439–45. PMID 9920888.
Kitagawa M, Hatakeyama S, Shirane M, et al. (1999). "An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.". EMBO J. 18 (9): 2401–10. doi:10.1093/emboj/18.9.2401. PMID 10228155.
Fagotto F, Jho E, Zeng L, et al. (1999). "Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.". J. Cell Biol. 145 (4): 741–56. PMID 10330403.
Kodama S, Ikeda S, Asahara T, et al. (1999). "Axin directly interacts with plakoglobin and regulates its stability.". J. Biol. Chem. 274 (39): 27682–8. PMID 10488109.
Jho E, Lomvardas S, Costantini F (2000). "A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.". Biochem. Biophys. Res. Commun. 266 (1): 28–35. doi:10.1006/bbrc.1999.1760. PMID 10581160.
Ikeda S, Kishida M, Matsuura Y, et al. (2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.". Oncogene 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.
Satoh S, Daigo Y, Furukawa Y, et al. (2000). "AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.". Nat. Genet. 24 (3): 245–50. doi:10.1038/73448. PMID 10700176.
Spink KE, Polakis P, Weis WI (2000). "Structural basis of the Axin-adenomatous polyposis coli interaction.". EMBO J. 19 (10): 2270–9. doi:10.1093/emboj/19.10.2270. PMID 10811618.
Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase.". J. Biol. Chem. 275 (32): 25008–14. doi:10.1074/jbc.M002491200. PMID 10829020.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
Yamamoto H, Hinoi T, Michiue T, et al. (2001). "Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.". J. Biol. Chem. 276 (29): 26875–82. doi:10.1074/jbc.M100443200. PMID 11297546.
Mao J, Wang J, Liu B, et al. (2001). "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.". Mol. Cell 7 (4): 801–9. PMID 11336703.
Furuhashi M, Yagi K, Yamamoto H, et al. (2001). "Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.". Mol. Cell. Biol. 21 (15): 5132–41. doi:10.1128/MCB.21.15.5132-5141.2001. PMID 11438668.
Rubinfeld B, Tice DA, Polakis P (2001). "Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.". J. Biol. Chem. 276 (42): 39037–45. doi:10.1074/jbc.M105148200. PMID 11487578.