Autoimmune disease

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Autoimmune disease Classification and external resources
ICD-9	279.4
OMIM	109100
DiseasesDB	28805
MedlinePlus	000816
MeSH	D001327

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells. Autoimmune diseases are a major cause of immune-mediated diseases.

Contents 1 Gender influence 2 Autoimmune diseases 3 References 4 External links

[edit] Gender influence

Women tend to be affected more often by autoimmune disorders; nearly 79% of autoimmune disease patients in the USA are women. Also they tend to appear during or shortly after puberty. It is not known why this is the case, although hormone levels have been shown to affect the severity of some autoimmune diseases such as multiple sclerosis.^[1] Other causes may include the presence of fetal cells in the maternal bloodstream. ^[2]

[edit] Autoimmune diseases

It is possible to classify autoimmune diseases by corresponding type of hypersensitivity: type II, type III, or type IV. (No type of autoimmune disease mimics type I hypersensitivity.)^[3]

Name	Accepted/ suspected	Hypersensitivity
Acute disseminated encephalomyelitis (ADEM)	Accepted[4]
Addison's disease	Accepted[4]
Ankylosing spondylitis	Accepted[4]
Antiphospholipid antibody syndrome (APS)	Accepted[4]
Autoimmune hemolytic anemia	Accepted[5]	II
Autoimmune hepatitis	Accepted[4]
Bullous pemphigoid	Accepted[5]
Coeliac disease	Accepted[6][7][8]	IV
Chagas disease	Suspected[9]
Chronic obstructive pulmonary disease	Suspected[10] [11]
Dermatomyositis	Accepted[12]
Diabetes mellitus type 1	Accepted[4]	IV
Endometriosis	Suspected[13]
Goodpasture's syndrome	Accepted[4]	II
Graves' disease	Accepted[4]	II
Guillain-Barré syndrome (GBS)	Accepted[4]
Hashimoto's disease	Accepted[4]
Hidradenitis suppurativa	Suspected[14]
Idiopathic thrombocytopenic purpura	Accepted[4]
Interstitial cystitis	Suspected[15]
Lupus erythematosus	Accepted[4]	III
Morphea	Suspected[16]
Multiple sclerosis	Accepted[4]	IV
Myasthenia gravis	Accepted[4]	II
Narcolepsy	Suspected[17]
Neuromyotonia	Suspected[18]
Pemphigus	Accepted[4]	II
Pernicious anaemia	Accepted[19]
Polymyositis	Accepted[12]
Primary biliary cirrhosis	Accepted[20]
Rheumatoid arthritis	Accepted[4]	IV
Schizophrenia.	Suspected[21][22][23]
Sjögren's syndrome	Accepted[4]
Temporal arteritis (also known as "giant cell arteritis")	Accepted[4]
Vasculitis	Accepted[5]
Vitiligo	Suspected[24][25]
Wegener's granulomatosis	Accepted[26]

[edit] References

[edit] External links

• Links to pictures of Autoimmune Diseases (Hardin MD) at University of Iowa

v • d • e Pathology: Immune disorders (primarily D80-D89, 273, 279) Immunodeficiency/ primary Antibody/humoral (B) Hypogammaglobulinemia/agammaglobulinemia (X-linked, Transient of infancy) - Dysgammaglobulinemia (IgA, IgG) - Common variable immunodefiency - WHIM syndrome Cell-mediated (T) DiGeorge syndrome - Nezelof syndrome Combined (B+T) Severe combined immunodeficiency (Adenosine deaminase deficiency, Omenn syndrome, X-SCID, ZAP70 deficiency) - Purine nucleoside phosphorylase deficiency - Bare lymphocyte syndrome - Wiskott-Aldrich syndrome Complement deficiency Angioedema PBD chemotaxis/degranulation (Leukocyte adhesion deficiency, Chédiak-Higashi syndrome, Hyper-IgE syndrome) redox (Chronic granulomatous disease, Myeloperoxidase deficiency) Other ICF syndrome Immunoproliferative Hypergammaglobulinemia Paraproteinemia (Cryoglobulinemia, Heavy chain disease, POEMS syndrome, Monoclonal gammopathy of undetermined significance) Lymphoproliferative disorders (Sarcoidosis) Hypersensitivity Type I (Allergy) - Type II - Type III (Serum sickness) - Type IV (Contact dermatitis) Autoimmunity/Autoimmune disease See also hematological malignancy and hematology