Aurora B kinase

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Aurora kinase B
Identifiers
Symbol(s) AURKB; AIM1; AIK2; AIM-1; ARK2; AurB; IPL1; STK12; STK5
External IDs OMIM: 604970 MGI: 107168 HomoloGene: 55807
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9212 20877
Ensembl ENSG00000178999 ENSMUSG00000020897
Uniprot Q96GD4 Q8C6C1
Refseq NM_004217 (mRNA)
NP_004208 (protein)		 NM_011496 (mRNA)
NP_035626 (protein)
Location Chr 17: 8.05 - 8.05 Mb Chr 11: 68.86 - 68.87 Mb
Pubmed search [1] [2]

Aurora B kinase is a human protein that functions in the attachment of the mitotic spindle to the centromere. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).[supplied by OMIM][1] In cancerous cells, over expression of these enzymes cause unequal distribution of genetic information creating aneuploidy cells, a hallmark of cancer.

[edit] References

  1. ^ Entrez Gene: AURKB aurora kinase B.

[edit] Further reading

  • Nigg EA (2001). "Mitotic kinases as regulators of cell division and its checkpoints.". Nat. Rev. Mol. Cell Biol. 2 (1): 21–32. doi:10.1038/35048096. PMID 11413462. 
  • Shindo M, Nakano H, Kuroyanagi H, et al. (1998). "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.". Biochem. Biophys. Res. Commun. 244 (1): 285–92. doi:10.1006/bbrc.1998.8250. PMID 9514916. 
  • Tatsuka M, Katayama H, Ota T, et al. (1998). "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.". Cancer Res. 58 (21): 4811–6. PMID 9809983. 
  • Kimura M, Matsuda Y, Yoshioka T, et al. (1999). "Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1.". Cytogenet. Cell Genet. 82 (3-4): 147–52. PMID 9858806. 
  • Katayama H, Ota T, Morita K, et al. (1999). "Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells.". Gene 224 (1-2): 1–7. PMID 9931403. 
  • Prigent C, Gill R, Trower M, Sanseau P (2001). "In silico cloning of a new protein kinase, Aik2, related to Drosophila Aurora using the new tool: EST Blast.". In Silico Biol. (Gedrukt) 1 (2): 123–8. PMID 11471245. 
  • Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.". Curr. Biol. 11 (11): 886–90. PMID 11516652. 
  • Zeitlin SG, Shelby RD, Sullivan KF (2002). "CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.". J. Cell Biol. 155 (7): 1147–57. doi:10.1083/jcb.200108125. PMID 11756469. 
  • Crosio C, Fimia GM, Loury R, et al. (2002). "Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.". Mol. Cell. Biol. 22 (3): 874–85. PMID 11784863. 
  • Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.". Genes Cells 7 (1): 11–7. PMID 11856369. 
  • Gigoux V, L'Hoste S, Raynaud F, et al. (2002). "Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins.". J. Biol. Chem. 277 (26): 23742–6. doi:10.1074/jbc.C200121200. PMID 11976319. 
  • Sugiyama K, Sugiura K, Hara T, et al. (2002). "Aurora-B associated protein phosphatases as negative regulators of kinase activation.". Oncogene 21 (20): 3103–11. doi:10.1038/sj.onc.1205432. PMID 12082625. 
  • Chen J, Jin S, Tahir SK, et al. (2003). "Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells.". J. Biol. Chem. 278 (1): 486–90. doi:10.1074/jbc.M211119200. PMID 12419797. 
  • Morrison C, Henzing AJ, Jensen ON, et al. (2002). "Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.". Nucleic Acids Res. 30 (23): 5318–27. PMID 12466558. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kawajiri A, Yasui Y, Goto H, et al. (2003). "Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase.". Mol. Biol. Cell 14 (4): 1489–500. doi:10.1091/mbc.E02-09-0612. PMID 12686604. 
  • Minoshima Y, Kawashima T, Hirose K, et al. (2003). "Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.". Dev. Cell 4 (4): 549–60. PMID 12689593. 
  • Honda R, Körner R, Nigg EA (2004). "Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.". Mol. Biol. Cell 14 (8): 3325–41. doi:10.1091/mbc.E02-11-0769. PMID 12925766. 
  • Tien AC, Lin MH, Su LJ, et al. (2004). "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.". Mol. Cell Proteomics 3 (1): 93–104. doi:10.1074/mcp.M300072-MCP200. PMID 14602875. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)
2.7.11
2.7.12
MAP2K (1, 2, 3, 4, 5, 6, 7)
2.7.1.37, or unknown