AURKC

From Wikipedia, the free encyclopedia

Aurora kinase C

Identifiers

AURKC; AIE2; AIK3; AurC; STK13; aurora-C

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus • centrosome
Biological Process:	• cytokinesis • protein amino acid phosphorylation • cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001015878 (mRNA)
NP_001015878 (protein)

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n/a (protein)

Location

Chr 19: 62.43 - 62.44 Mb

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Pubmed search

[1]

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Aurora kinase C, also known as AURKC, is a human gene.^[1]

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: AURKC aurora kinase C.

[edit] Further reading

Katayama H, Brinkley WR, Sen S (2004). "The Aurora kinases: role in cell transformation and tumorigenesis.". Cancer Metastasis Rev. 22 (4): 451-64. PMID 12884918.
Bernard M, Sanseau P, Henry C, et al. (1998). "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter.". Genomics 53 (3): 406-9. doi:10.1006/geno.1998.5522. PMID 9799611.
Tseng TC, Chen SH, Hsu YP, Tang TK (1998). "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.". DNA Cell Biol. 17 (10): 823-33. PMID 9809744.
Kimura M, Matsuda Y, Yoshioka T, Okano Y (1999). "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3.". J. Biol. Chem. 274 (11): 7334-40. PMID 10066797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960-3. doi:10.1126/science.1088821. PMID 14671302.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Li X, Sakashita G, Matsuzaki H, et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.". J. Biol. Chem. 279 (45): 47201-11. doi:10.1074/jbc.M403029200. PMID 15316025.
Sasai K, Katayama H, Stenoien DL, et al. (2005). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.". Cell Motil. Cytoskeleton 59 (4): 249-63. doi:10.1002/cm.20039. PMID 15499654.
Yan X, Wu Y, Li Q, et al. (2005). "Cloning and characterization of a novel human Aurora C splicing variant.". Biochem. Biophys. Res. Commun. 328 (1): 353-61. doi:10.1016/j.bbrc.2004.12.168. PMID 15670791.
Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.". J. Biomed. Sci. 12 (2): 297-310. doi:10.1007/s11373-005-0980-0. PMID 15917996.
Yan X, Cao L, Li Q, et al. (2005). "Aurora C is directly associated with Survivin and required for cytokinesis.". Genes Cells 10 (6): 617-26. doi:10.1111/j.1365-2443.2005.00863.x. PMID 15938719.
Dutertre S, Hamard-Péron E, Cremet JY, et al. (2006). "The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression.". Cell Cycle 4 (12): 1783-7. PMID 16258285.
Dieterich K, Soto Rifo R, Faure AK, et al.. "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.". Nat. Genet. 39 (5): 661-5. doi:10.1038/ng2027. PMID 17435757.