AUP1

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Ancient ubiquitous protein 1
Identifiers
Symbol(s) AUP1;
External IDs OMIM: 602434 MGI: 107789 HomoloGene: 7239
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 550 11993
Ensembl ENSG00000115307 ENSMUSG00000068328
Uniprot Q9Y679 Q0P6G8
Refseq NM_181575 (mRNA)
NP_853553 (protein)		 NM_007517 (mRNA)
NP_031543 (protein)
Location Chr 2: 74.61 - 74.61 Mb Chr 6: 83.02 - 83.02 Mb
Pubmed search [1] [2]

Ancient ubiquitous protein 1, also known as AUP1, is a human gene.[1]

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.[1]

[edit] References

  1. ^ a b Entrez Gene: AUP1 ancient ubiquitous protein 1.

[edit] Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Karpisheva KV, Tauber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines]". Tsitologiia 44 (9): 846-51. PMID 12534238. 
  • Karpisheva KV, Touber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans preliminary characterization of human AUP1 protein]". Tsitologiia 44 (9): 839-45. PMID 12534237. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kato A, Kawamata N, Tamayose K, et al. (2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.". J. Biol. Chem. 277 (32): 28934-41. doi:10.1074/jbc.M204340200. PMID 12042322. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152. 
  • Jang W, Weber JS, Bashir R, et al. (1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13.". Genomics 36 (2): 366-8. doi:10.1006/geno.1996.0477. PMID 8812468. 
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