ATRN

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For the ATRN Extended SMTP command, see On-Demand Mail Relay.

Attractin

Identifiers

ATRN; DPPT-L; KIAA0548; MGC126754; MGCA

External IDs

OMIM: 603130 MGI: 1341628 HomoloGene: 22542

Gene ontology
Molecular Function:	• receptor activity • protein binding • sugar binding
Cellular Component:	• extracellular space • plasma membrane • integral to plasma membrane
Biological Process:	• inflammatory response • multicellular organismal development • regulation of body size

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_139321 (mRNA)
NP_647537 (protein)

NM_009730 (mRNA)
NP_033860 (protein)

Location

Chr 20: 3.4 - 3.58 Mb

Chr 2: 130.6 - 130.72 Mb

Pubmed search

[1]

[2]

Attractin, also known as ATRN, is a human gene.^[1]

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATRN attractin.

[edit] Further reading

Mori M, Sakurai M, Araie M (1993). "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon Ganka Gakkai Zasshi 96 (11): 1418-22. PMID 1476071.
Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF (1996). "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells.". J. Immunol. 156 (5): 1714-21. PMID 8596018.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
Duke-Cohan JS, Gu J, McLaughlin DF, et al. (1998). "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11336-41. PMID 9736737.
Nagle DL, McGrail SH, Vitale J, et al. (1999). "The mahogany protein is a receptor involved in suppression of obesity.". Nature 398 (6723): 148-52. doi:10.1038/18210. PMID 10086355.
Gunn TM, Miller KA, He L, et al. (1999). "The mouse mahogany locus encodes a transmembrane form of human attractin.". Nature 398 (6723): 152-6. doi:10.1038/18217. PMID 10086356.
Tang W, Gunn TM, McLaughlin DF, et al. (2000). "Secreted and membrane attractin result from alternative splicing of the human ATRN gene.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6025-30. doi:10.1073/pnas.110139897. PMID 10811918.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU (2003). "Isolation and characterization of attractin-2.". Adv. Exp. Med. Biol. 524: 109-13. PMID 12675230.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454-65. doi:10.1002/pmic.200300556. PMID 14760718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Wrenger S, Faust J, Friedrich D, et al. (2007). "Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.". J. Leukoc. Biol. 80 (3): 621-9. doi:10.1189/jlb.1105678. PMID 16835316.