ATP synthase chain A

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ATP synthase A chain
Identifiers
Symbol	ATP-synt_A
Pfam	PF00119
InterPro	IPR000568
PROSITE	PDOC00420
SCOP	1c17
OPM family	5
OPM protein	1c17
Available PDB structures: 1ed3C:29-41 1c17M:95-266

ATP synthase F0 subunit 6

Identifiers

Symbol(s)

ATP6; MTATP6

External IDs

MGI: 99927 HomoloGene: 5012

Gene ontology

Orthologs

Human

Mouse

Refseq

n/a (mRNA)
NP_536848 (protein)

n/a (mRNA)
NP_904333 (protein)

Location

Chr MT: 0.01 - 0.01 Mb

Pubmed search

[1]

[2]

ATP synthase F0 subunit 6 (or subunit/chain A) (human gene name ATP6) is a subunit of F0 complex of transmembrane F-type ATP synthase.

This subunit is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring, which in turn is driven by the flux of protons through the membrane via the interface between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain, and is thought to act as a stator to counter the tendency of subunit A and the F1alpha(3)beta(3) catalytic portion to rotate with the central rotary element^[1].

3D structure of E.coli homologue of this subunit was modelled based on electron microscopy data (chain M of PDB 1c17). It forms a transmembrane 4-α-bundle.

[edit] References

^ Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA (2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". J. Mol. Biol. 351 (4): 824–838. doi:10.1016/j.jmb.2005.06.012. PMID 16045926.

[edit] Further reading

Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339–45. doi:10.1016/j.tig.2006.04.001. PMID 16678300.
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708–13. doi:10.1038/35047064. PMID 11130070.
Manfredi G, Fu J, Ojaimi J, et al. (2002). "Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.". Nat. Genet. 30 (4): 394–9. doi:10.1038/ng851. PMID 11925565.
Torigoe T, Izumi H, Ishiguchi H, et al. (2002). "Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents.". J. Biol. Chem. 277 (39): 36534–43. doi:10.1074/jbc.M202605200. PMID 12133827.
Mishmar D, Ruiz-Pesini E, Golik P, et al. (2003). "Natural selection shaped regional mtDNA variation in humans.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 171–6. doi:10.1073/pnas.0136972100. PMID 12509511.
Ingman M, Gyllensten U (2003). "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.". Genome Res. 13 (7): 1600–6. doi:10.1101/gr.686603. PMID 12840039.
Kong QP, Yao YG, Sun C, et al. (2003). "Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.". Am. J. Hum. Genet. 73 (3): 671–6. doi:10.1086/377718. PMID 12870132.
Temperley RJ, Seneca SH, Tonska K, et al. (2004). "Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria.". Hum. Mol. Genet. 12 (18): 2341–8. doi:10.1093/hmg/ddg238. PMID 12915481.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. PMID 14499622.
Dubot A, Godinot C, Dumur V, et al. (2004). "GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene.". Biochem. Biophys. Res. Commun. 313 (3): 687–93. PMID 14697245.
Coble MD, Just RS, O'Callaghan JE, et al. (2004). "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.". Int. J. Legal Med. 118 (3): 137–46. doi:10.1007/s00414-004-0427-6. PMID 14760490.
Carrozzo R, Rizza T, Stringaro A, et al. (2004). "Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis.". J. Neurochem. 90 (2): 490–501. doi:10.1111/j.1471-4159.2004.02505.x. PMID 15228605.