ATP citrate lyase
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ATP citrate lyase
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| Identifiers | |
| Symbol | ACLY |
| Entrez | 47 |
| HUGO | 115 |
| OMIM | 108728 |
| RefSeq | NM_001096 |
| UniProt | P53396 |
| Other data | |
| EC number | 2.3.3.8 |
| Locus | Chr. 17 q21.2 |
ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis.
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[edit] Reaction
In the presence of ATP and Coenzyme A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and orthophosphate:
- citrate + ATP + CoA-->oxaloacetate + Acetyl-CoA + ADP + Pi.
This enzyme was formerly listed as EC 4.1.3.8.[1]
[edit] Location
The enzyme is cytosolic in plants[2] and animals.
[edit] Structure
The enzyme is composed of two subunits in green plants (including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots), species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes.
Animal ACL enzymes are homomeric, presumably an evolutionary fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.[3]
[edit] References
- ^ MeSH ATP+Citrate+Lyase
- ^ Kaethner TM, ap Rees T. Planta. 1985;163:290;[1]
- ^ Molecular Characterization of a Heteromeric ATP-Citrate Lyase That Generates Cytosolic Acetyl-Coenzyme A in Arabidopsis - Fatland et al. 130 (2): 740 - PLANT PHYSIOLOGY
This article incorporates text from the National Library of Medicine, a public domain work of the United States Government.
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