ATP6V1A

From Wikipedia, the free encyclopedia

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A

Identifiers

ATP6V1A; ATP6A1; ATP6V1A1; HO68; VA68; VPP2; Vma1

External IDs

OMIM: 607027 MGI: 1201780 HomoloGene: 1277

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • hydrolase activity • metal ion binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• mitochondrion • integral to plasma membrane • proton-transporting two-sector ATPase complex
Biological Process:	• ion transport • ATP synthesis coupled proton transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001690 (mRNA)
NP_001681 (protein)

NM_007508 (mRNA)
NP_031534 (protein)

Location

Chr 3: 114.95 - 115.01 Mb

Chr 16: 44.01 - 44.06 Mb

Pubmed search

[1]

[2]

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A, also known as ATP6V1A, is a human gene.^[1]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A.

[edit] Further reading

Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes.". Biochem. J. 324 ( Pt 3): 697-712. PMID 9210392.
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase.". Annu. Rev. Cell Dev. Biol. 13: 779-808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases.". Physiol. Rev. 79 (2): 361-85. PMID 10221984.
Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases.". J. Biol. Chem. 274 (19): 12951-4. PMID 10224039.
Kane PM (1999). "Introduction: V-ATPases 1992-1998.". J. Bioenerg. Biomembr. 31 (1): 3-5. PMID 10340843.
Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases.". Bioessays 21 (8): 637-48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps.". Nat. Rev. Mol. Cell Biol. 3 (2): 94-103. doi:10.1038/nrm729. PMID 11836511.
Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases.". FEBS Lett. 545 (1): 76-85. PMID 12788495.
Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase.". Biol. Cell 95 (7): 453-7. PMID 14597263.
van Hille B, Richener H, Green JR, Bilbe G (1995). "The ubiquitous VA68 isoform of subunit A of the vacuolar H(+)-ATPase is highly expressed in human osteoclasts.". Biochem. Biophys. Res. Commun. 214 (3): 1108-13. PMID 7575517.
van Hille B, Richener H, Evans DB, et al. (1993). "Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.". J. Biol. Chem. 268 (10): 7075-80. PMID 8463241.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation.". J. Biol. Chem. 277 (10): 8388-94. doi:10.1074/jbc.M108792200. PMID 11741979.