ATP5S

From Wikipedia, the free encyclopedia

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)

Identifiers

ATP5S; ATPW; HSU79253

External IDs

MGI: 1915305 HomoloGene: 12232

Gene ontology
Molecular Function:	• hydrogen ion transmembrane transporter activity
Cellular Component:	• mitochondrion • proton-transporting ATP synthase complex, coupling factor F(o)
Biological Process:	• ion transport • proton transport

RNA expression pattern

Image:PBB GE ATP5S 206992 s at tn.png

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001003803 (mRNA)
NP_001003803 (protein)

NM_026536 (mRNA)
NP_080812 (protein)

Location

Chr 14: 49.85 - 49.87 Mb

Chr 12: 70.64 - 70.66 Mb

Pubmed search

[1]

[2]

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B), also known as ATP5S, is a human gene.^[1]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B).

[edit] Further reading

Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine.". Essays Biochem. 35: 3–18. PMID 12471886.
Oster G, Wang H (2003). "Rotary protein motors.". Trends Cell Biol. 13 (3): 114–21. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review).". Mol. Membr. Biol. 20 (1): 27–33. PMID 12745923.
Sanadi DR, Pringle M, Kantham L, et al. (1984). "Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase.". Proc. Natl. Acad. Sci. U.S.A. 81 (5): 1371–4. PMID 6143319.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
Belogrudov GI, Hatefi Y (2002). "Factor B and the mitochondrial ATP synthase complex.". J. Biol. Chem. 277 (8): 6097–103. doi:10.1074/jbc.M111256200. PMID 11744738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.