ATP5J

From Wikipedia, the free encyclopedia

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6

Identifiers

ATP5J; ATP5A; ATPM; ATP5; CF6; F6

External IDs

OMIM: 603152 MGI: 107777 HomoloGene: 1272

Gene ontology
Molecular Function:	• transporter activity • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• membrane fraction • mitochondrion • mitochondrial inner membrane • proton-transporting two-sector ATPase complex • proton-transporting ATP synthase complex, coupling factor F(o)
Biological Process:	• generation of precursor metabolites and energy • ion transport • ATP synthesis coupled proton transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001003696 (mRNA)
NP_001003696 (protein)

NM_016755 (mRNA)
NP_058035 (protein)

Location

Chr 21: 26.02 - 26.03 Mb

n/a

Pubmed search

[1]

[2]

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6, also known as ATP5J, is a human gene.^[1]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the F0 complex, required for F1 and F0 interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP5J ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6.

[edit] Further reading

Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine.". Essays Biochem. 35: 3-18. PMID 12471886.
Oster G, Wang H (2003). "Rotary protein motors.". Trends Cell Biol. 13 (3): 114-21. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review).". Mol. Membr. Biol. 20 (1): 27-33. PMID 12745923.
Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992-1001. PMID 1286669.
Javed AA, Ogata K, Sanadi DR (1991). "Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6.". Gene 97 (2): 307-10. PMID 1825642.
Higuti T, Tsurumi C, Kawamura Y, et al. (1991). "Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria.". Biochem. Biophys. Res. Commun. 178 (2): 793-9. PMID 1830479.
Yan WL, Lerner TJ, Haines JL, Gusella JF (1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3).". Genomics 24 (2): 375-7. doi:10.1006/geno.1994.1631. PMID 7698763.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature 391 (6666): 510-3. doi:10.1038/35185. PMID 9461222.
Webster KA, Oliver NA, Wallace DC (1998). "Assignment of an oligomycin-resistance locus to human chromosome 10.". Somatic Cell Genet. 8 (2): 223-44. PMID 9732751.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279-82. doi:10.1038/24409. PMID 9834036.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Osanai T, Nakamura M, Sasaki S, et al. (2004). "Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.". Kidney Int. 64 (6): 2291-7. doi:10.1046/j.1523-1755.2003.00334.x. PMID 14633154.
Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407-8. doi:10.1038/427407b. PMID 14749816.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jacobs LJ, de Coo IF, Nijland JG, et al. (2005). "Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation.". Mol. Hum. Reprod. 11 (3): 223-8. doi:10.1093/molehr/gah152. PMID 15709156.