ATP5G3

From Wikipedia, the free encyclopedia

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

Identifiers

ATP5G3; MGC125738; P3

External IDs

OMIM: 602736 MGI: 2442035 HomoloGene: 1276

Gene ontology
Molecular Function:	• transporter activity • protein binding • lipid binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• membrane fraction • mitochondrion • mitochondrial proton-transporting ATP synthase complex • membrane • proton-transporting two-sector ATPase complex • proton-transporting ATP synthase complex, coupling factor F(o)
Biological Process:	• generation of precursor metabolites and energy • ion transport • ATP synthesis coupled proton transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001002258 (mRNA)
NP_001002258 (protein)

NM_175015 (mRNA)
NP_778180 (protein)

Location

Chr 2: 175.75 - 175.76 Mb

Chr 2: 73.71 - 73.71 Mb

Pubmed search

[1]

[2]

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9), also known as ATP5G3, is a human gene.^[1]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP5G3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9).

[edit] Further reading

Farrell LB, Nagley P (1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.". Biochem. Biophys. Res. Commun. 144 (3): 1257-64. PMID 2883974.
Yan WL, Lerner TJ, Haines JL, Gusella JF (1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3).". Genomics 24 (2): 375-7. doi:10.1006/geno.1994.1631. PMID 7698763.
Dyer MR, Walker JE (1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.". Biochem. J. 293 ( Pt 1): 51-64. PMID 8328972.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature 391 (6666): 510-3. doi:10.1038/35185. PMID 9461222.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279-82. doi:10.1038/24409. PMID 9834036.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407-8. doi:10.1038/427407b. PMID 14749816.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.