ATP5E

From Wikipedia, the free encyclopedia

ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit

PDB rendering based on 1e79.

Available structures: 1e79, 1h8e, 2ck3, 2jdi

Identifiers

Symbol(s)

ATP5E; ATPE; MGC104243

External IDs

OMIM: 606153

Gene ontology
Molecular Function:	• hydrolase activity • metal ion binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• mitochondrion • mitochondrial proton-transporting ATP synthase complex • proton-transporting two-sector ATPase complex • proton-transporting ATP synthase complex, catalytic core F(1)
Biological Process:	• ion transport • ATP synthesis coupled proton transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001001977 (mRNA)
NP_001001977 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 20: 57.04 - 57.04 Mb

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Pubmed search

[1]

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ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit, also known as ATP5E, is a human gene.^[1]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit.

[edit] Further reading

Viñas O, Powell SJ, Runswick MJ, et al. (1990). "The epsilon-subunit of ATP synthase from bovine heart mitochondria. Complementary DNA sequence, expression in bovine tissues and evidence of homologous sequences in man and rat.". Biochem. J. 265 (2): 321-6. PMID 2137333.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature 391 (6666): 510-3. doi:10.1038/35185. PMID 9461222.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279-82. doi:10.1038/24409. PMID 9834036.
Tu Q, Yu L, Zhang P, et al. (2000). "Cloning, characterization and mapping of the human ATP5E gene, identification of pseudogene ATP5EP1, and definition of the ATP5E motif.". Biochem. J. 347 Pt 1: 17-21. PMID 10727396.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Gross C, Kussmann S, Hehr A, et al. (2001). "Epsilon subunit gene of F(1)F(0)-ATP synthase (ATP5E) on human chromosome 20q13.2-->q13.3 localizes between D20S171 and GNAS1.". Cytogenet. Cell Genet. 91 (1-4): 105-6. PMID 11173840.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407-8. doi:10.1038/427407b. PMID 14749816.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.