ATP5D

From Wikipedia, the free encyclopedia

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

PDB rendering based on 1e79.

Available structures: 1e79, 1h8e, 2ck3, 2jdi

Identifiers

Symbol(s)

ATP5D;

External IDs

OMIM: 603150 MGI: 1913293 HomoloGene: 37514

Gene ontology
Molecular Function:	• transporter activity • hydrolase activity • metal ion binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• membrane fraction • mitochondrion • mitochondrial proton-transporting ATP synthase complex • proton-transporting two-sector ATPase complex • proton-transporting ATP synthase complex, catalytic core F(1)
Biological Process:	• ion transport • ATP synthesis coupled proton transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001001975 (mRNA)
NP_001001975 (protein)

NM_025313 (mRNA)
NP_079589 (protein)

Location

Chr 19: 1.19 - 1.2 Mb

Chr 10: 79.55 - 79.55 Mb

Pubmed search

[1]

[2]

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, also known as ATP5D, is a human gene.^[1]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit.

[edit] Further reading

Yoshida M, Muneyuki E, Hisabori T (2001). "ATP synthase--a marvellous rotary engine of the cell.". Nat. Rev. Mol. Cell Biol. 2 (9): 669-77. doi:10.1038/35089509. PMID 11533724.
Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992-1001. PMID 1286669.
Jordan EM, Breen GA (1992). "Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex.". Biochim. Biophys. Acta 1130 (1): 123-6. PMID 1531933.
Yasuda R, Noji H, Kinosita K, Yoshida M (1998). "F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps.". Cell 93 (7): 1117-24. PMID 9657145.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279-82. doi:10.1038/24409. PMID 9834036.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407-8. doi:10.1038/427407b. PMID 14749816.
Itoh H, Takahashi A, Adachi K, et al. (2004). "Mechanically driven ATP synthesis by F1-ATPase.". Nature 427 (6973): 465-8. doi:10.1038/nature02212. PMID 14749837.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.