ATP1B3
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ATPase, Na+/K+ transporting, beta 3 polypeptide
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| Identifiers | ||||||||||||||
| Symbol(s) | ATP1B3; ATPB-3; CD298; FLJ29027 | |||||||||||||
| External IDs | OMIM: 601867 MGI: 107788 HomoloGene: 37510 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 483 | 11933 | ||||||||||||
| Ensembl | ENSG00000069849 | ENSMUSG00000032412 | ||||||||||||
| Uniprot | P54709 | Q1WWL1 | ||||||||||||
| Refseq | XM_001133533 (mRNA) XP_001133533 (protein) |
NM_007502 (mRNA) NP_031528 (protein) |
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| Location | Chr 3: 143.08 - 143.13 Mb | Chr 9: 96.14 - 96.17 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
ATPase, Na+/K+ transporting, beta 3 polypeptide, also known as ATP1B3, is a human gene.[1] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.[1]
[edit] References
[edit] Further reading
- Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase.". Prog. Nucleic Acid Res. Mol. Biol. 38: 37-89. PMID 2158121.
- Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase.". Biochim. Biophys. Acta 694 (1): 27-68. PMID 6289898.
- Malik N, Canfield VA, Beckers MC, et al. (1996). "Identification of the mammalian Na,K-ATPase 3 subunit.". J. Biol. Chem. 271 (37): 22754-8. PMID 8798450.
- Malik N, Canfield V, Sanchez-Watts G, et al. (1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene.". Mamm. Genome 9 (2): 136-43. PMID 9457675.
- Chiampanichayakul S, Szekeres A, Khunkaewla P, et al. (2003). "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation.". Int. Immunol. 14 (12): 1407-14. PMID 12456588.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660-6. doi:. PMID 12754519.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135-44. doi:. PMID 17081065.
- Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells.". Tissue Antigens 68 (6): 509-17. doi:. PMID 17176442.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:. PMID 17353931.
- Aughey RJ, Murphy KT, Clark SA, et al. (2007). "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.". J. Appl. Physiol. 103 (1): 39-47. doi:. PMID 17446412.
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