ATP1A4

From Wikipedia, the free encyclopedia

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Identifiers

ATP1A4; ATP1A1; ATP1AL2; MGC25056

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • catalytic activity • sodium:potassium-exchanging ATPase activity • ATP binding • monovalent inorganic cation transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism • hydrolase activity • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances • potassium ion binding • sodium ion binding
Cellular Component:	• sodium:potassium-exchanging ATPase complex • membrane
Biological Process:	• transport • cation transport • potassium ion transport • sodium ion transport • metabolic process • ATP hydrolysis coupled proton transport • sperm motility • cellular hydrogen ion homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001001734 (mRNA)
NP_001001734 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 158.39 - 158.42 Mb

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Pubmed search

[1]

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ATPase, Na+/K+ transporting, alpha 4 polypeptide, also known as ATP1A4, is a human gene.^[1]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide.

[edit] Further reading

Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na, K-ATPase.". Prog. Nucleic Acid Res. Mol. Biol. 38: 37-89. PMID 2158121.
Buetow KH, Nishimura D, Nakamura Y, et al. (1991). "A detailed multipoint gene map of chromosome 1q.". Genomics 8 (1): 13-21. PMID 1981991.
Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.". FEBS Lett. 221 (1): 129-33. PMID 2887455.
Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039-43. PMID 3035563.
Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.". FEBS Lett. 217 (2): 275-8. PMID 3036582.
Shamraj OI, Lingrel JB (1995). "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12952-6. PMID 7809153.
Woo AL, James PF, Lingrel JB (1999). "Characterization of the fourth alpha isoform of the Na, K-ATPase.". J. Membr. Biol. 169 (1): 39-44. PMID 10227850.
Woo AL, James PF, Lingrel JB (2000). "Sperm motility is dependent on a unique isoform of the Na, K-ATPase.". J. Biol. Chem. 275 (27): 20693-9. doi:10.1074/jbc. M002323200. PMID 10764792.
Woo AL, James PF, Lingrel JB (2003). "Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility.". Mol. Reprod. Dev. 62 (3): 348-56. doi:10.1002/mrd.90002. PMID 12112599.
Keryanov S, Gardner KL (2002). "Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4.". Gene 292 (1-2): 151-66. PMID 12119109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lingrel J, Moseley A, Dostanic I, et al. (2003). "Functional roles of the alpha isoforms of the Na, K-ATPase.". Ann. N. Y. Acad. Sci. 986: 354-9. PMID 12763850.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hlivko JT, Chakraborty S, Hlivko TJ, et al. (2006). "The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm.". Mol. Reprod. Dev. 73 (1): 101-15. doi:10.1002/mrd.20383. PMID 16175638.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Rodova M, Nguyen AN, Blanco G (2006). "The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform.". Mol. Reprod. Dev. 73 (11): 1435-47. doi:10.1002/mrd.20518. PMID 16894555.