ATP12A

From Wikipedia, the free encyclopedia

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Identifiers

ATP12A; ATP1AL1

External IDs

OMIM: 182360 MGI: 1926943 HomoloGene: 68197

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • ATP binding • hydrogen:potassium-exchanging ATPase activity • hydrolase activity • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances • potassium ion binding
Cellular Component:	• hydrogen:potassium-exchanging ATPase complex • membrane • integral to membrane
Biological Process:	• potassium ion transport • metabolic process • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001676 (mRNA)
NP_001667 (protein)

NM_138652 (mRNA)
NP_619593 (protein)

Location

Chr 13: 24.15 - 24.18 Mb

Chr 14: 55.32 - 55.34 Mb

Pubmed search

[1]

[2]

ATPase, H+/K+ transporting, nongastric, alpha polypeptide, also known as ATP12A, is a human gene.^[1]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide.

[edit] Further reading

Modyanov NN, Petrukhin KE, Sverdlov VE, et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.". FEBS Lett. 278 (1): 91-4. PMID 1847115.
Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.". Genomics 2 (2): 128-38. PMID 2842249.
Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039-43. PMID 3035563.
Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.". FEBS Lett. 217 (2): 275-8. PMID 3036582.
Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family.". FEBS Lett. 349 (1): 144-50. PMID 8045293.
Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase.". Genomics 32 (3): 317-27. doi:10.1006/geno.1996.0125. PMID 8838794.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Pestov NB, Romanova LG, Korneenko TV, et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.". FEBS Lett. 440 (3): 320-4. PMID 9872395.
Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization.". Am. J. Physiol., Cell Physiol. 282 (4): C907-16. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.". Am. J. Physiol. Renal Physiol. 283 (2): F335-43. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
Takahashi Y, Sakai H, Kuragari M, et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.". Jpn. J. Physiol. 52 (3): 317-21. PMID 12230809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function.". Kidney Int. 65 (4): 1301-10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast.". Placenta 25 (6): 505-11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.