ATP11B

From Wikipedia, the free encyclopedia

ATPase, Class VI, type 11B

Identifiers

ATP11B; ATPIF; ATPIR; DKFZP434J238; DKFZP434N1615; KIAA0956; MGC46576

External IDs

OMIM: 605869 MGI: 1923545 HomoloGene: 32919

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • phospholipid-translocating ATPase activity • ATP binding • ion transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism • hydrolase activity • ATPase activity
Cellular Component:	• nuclear inner membrane • membrane • integral to membrane
Biological Process:	• transport • cation transport • metabolic process • aminophospholipid transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_014616 (mRNA)
NP_055431 (protein)

NM_029570 (mRNA)
NP_083846 (protein)

Location

Chr 3: 183.99 - 184.12 Mb

Chr 3: 35.97 - 36.05 Mb

Pubmed search

[1]

[2]

ATPase, Class VI, type 11B, also known as ATP11B, is a human gene.^[1]

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ATP11B ATPase, Class VI, type 11B.

[edit] Further reading

Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194-8. doi:10.1038/nature04728. PMID 16641997.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Halleck MS, Schlegel RA, Williamson PL (2002). "Reanalysis of ATP11B, a type IV P-type ATPase.". J. Biol. Chem. 277 (12): 9736-40. doi:10.1074/jbc.M200240200. PMID 11790799.
Halleck MS, Lawler JF JR, Blackshaw S, et al. (2001). "Differential expression of putative transbilayer amphipath transporters.". Physiol. Genomics 1 (3): 139-50. PMID 11015572.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63-70. PMID 10231032.